L-Thyroxine sodium salt pentahydrate

• Catalog No.: 89430
• CAS Number: 6106-07-6
• M. F.: C15H20I4NNaO9
• M. W.: 888.92825
• Purity: ≥97.0% (sum of enantiomers, HPLC)

SYNONYMS

• Title: L-甲状腺素 钠盐 五水合物
• IUPAC name: sodium (2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoate pentahydrate
• IUPAC Traditional name: sodium levothyroxine(1-) pentahydrate
• Synonyms: 左旋甲状腺素钠; Sodium levothyroxine; 3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanine sodium salt; 3-[4-(4-羟基-3,5-二碘苯氧基)-3,5-二碘苯基]-L-丙氨酸 钠盐; T4

DATABASE IDS

• Beilstein Number: 5721845
• EC Number: 200-221-4
• CAS Number: 6106-07-6
• MDL Number: MFCD00149110

PROPERTIES

• Impurities: ~10% water
• Linear Formula: HOC6H2I2OC6H2I2CH2CH(NH2)COONa · 5H2O
• Purity: ≥97.0% (sum of enantiomers, HPLC)
• Melting Point: 207-210 (dec.)(lit.)
• Optical Rotation: [α]20/D +16±1°, c = 2% in ethanol/1 M HCl (4:1)
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS: YP2833760
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Application
Literatur s. 89405, L-Thyroxine
Biochem/physiol Actions
L-Thyroxine (T4) and triiodo-L-thyronine (T3) are iodine-containing hormones produced from thyroglobulin in the thyroid follicular cells. The stimulation of metabolic rate and regulation of growth and development by these hormones appear to be due to their effects on DNA transcription and thus, protein synthesis.

Description (简体中文)

Application
Literatur s. 89405, L-Thyroxine
Biochem/physiol Actions
L甲状腺素 (T4) 和三碘代-L-甲状腺原氨酸 (T3) 是含碘的激素，由甲状腺滤泡细胞中的甲状腺球蛋白形成。这些激素对代谢率的刺激以及对生长发育的调节似乎归因于它们对 DNA 转录的作用，进而影响蛋白质的合成。