4-Maleimidobutyric acid N-hydroxysuccinimide ester

• Catalog No.: 63175
• CAS Number: 80307-12-6
• M. F.: C12H12N2O6
• M. W.: 280.23348
• Purity: ≥98.0% (HPLC)

SYNONYMS

• IUPAC name: 2,5-dioxopyrrolidin-1-yl 4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)butanoate
• IUPAC Traditional name: 2,5-dioxopyrrolidin-1-yl 4-(2,5-dioxopyrrol-1-yl)butanoate
• Synonyms: 4-Maleimidobutyric acid N-succinimidyl ester; N-(γ-Maleimidobutyryloxy)succinimide; GMBS; N-Succinimidyl 4-maleimidobutyrate

DATABASE IDS

• MDL Number: MFCD00036817
• Beilstein Number: 6427689
• CAS Number: 80307-12-6
• PubChem SID: 24882441

PROPERTIES

• Empirical Formula (Hill Notation): C12H12N2O6
• Purity: ≥98.0% (HPLC)
• Melting Point: 123-129 °C
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Application
A heterobifunctional cross-linking reagent with amine and sulfhydryl reactivity. Typically, coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). Second coupling specific for molecules containing free sulfhydryl by thioether linkage buffered at pH 6.8 (6.5-7.0). Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates. Provides a 7-atom linker.

Description (简体中文)

Application
A heterobifunctional cross-linking reagent with amine and sulfhydryl reactivity. Typically, coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). Second coupling specific for molecules containing free sulfhydryl by thioether linkage buffered at pH 6.8 (6.5-7.0). Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates. Provides a 7-atom linker.