Dexamethasone

• Catalog No.: 31375
• CAS Number: 50-02-2
• M. F.: C22H29FO5
• M. W.: 392.4610632

SYNONYMS

• Title: 地塞米松
• IUPAC name: (1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadeca-3,6-dien-5-one
• IUPAC Traditional name: dexamethasone
• Synonyms: 德沙美松; 地塞米松; 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione; Prednisolone F; 9α-氟-16α-甲基氢化泼尼松; Dexamethasonum; (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione; 9α-Fluoro-16α-methylprednisolone; 21α-乙酰氧基-9α-氟-11β,17α-二羟基-16α-甲基孕甾-1,4-二烯-3,20-二酮; 9-氟-11,17,21-三羟基-16-甲基(11b,16a)-孕甾-1,4-二烯-3,20-二酮

DATABASE IDS

• CAS Number: 50-02-2
• Beilstein Number: 2066651
• EC Number: 200-003-9
• MDL Number: MFCD00064136
• PubChem SID: 24858929

PROPERTIES

• Empirical Formula (Hill Notation): C22H29FO5
• Grade: Ph Eur
• Pharmacopeia: testing & handling conforms to Pharmacopeia
• Gene Information: human ... ABCB1(5243), CYP3A4(1576), IL4(3565), IL5(3567), NR3C1(2908)mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126), Ptgs2(19225), Tnf(21926)rat ... Ar(24208), Nr3c1(24413), Tnf(24835)
• Melting Point: 262-264 °C(lit.)
• GHS Signal Word: Danger
• GHS Hazard statements: H315-H317-H319-H334-H335
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS Precautionary statements: P261-P280-P305 + P351 + P338-P342 + P311
• Risk Statements: 36/37/38-42/43
• RTECS: TU3980000
• Safety Statements: 22-26-36/37-45
• German water hazard class: 2

DETAILS

Description (English)

Biochem/physiol Actions
Glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase.

Description (简体中文)

Biochem/physiol Actions
糖皮质素抗炎剂。调控 T 细胞的存活、生长和分化。抑制一氧化氮合酶的诱导作用。