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Dexamethasone

Catalog No. 31375 Name Sigma Aldrich
CAS Number 50-02-2 Website http://www.sigmaaldrich.com
M. F. C22H29FO5 Telephone 1-800-521-8956
M. W. 392.4610632 Fax
Purity Email
Storage Chembase ID: 1103

SYNONYMS

Title
地塞米松
IUPAC name
(1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one
IUPAC Traditional name
dexamethasone
Synonyms
德沙美松
地塞米松
9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione
Prednisolone F
9α-氟-16α-甲基氢化泼尼松
Dexamethasonum
(11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
9α-Fluoro-16α-methylprednisolone
21α-乙酰氧基-9α-氟-11β,17α-二羟基-16α-甲基孕甾-1,4-二烯-3,20-二酮
9-氟-11,17,21-三羟基-16-甲基(11b,16a)-孕甾-1,4-二烯-3,20-二酮

DATABASE IDS

CAS Number 50-02-2
Beilstein Number 2066651
EC Number 200-003-9
MDL Number MFCD00064136
PubChem SID 24858929

PROPERTIES

Empirical Formula (Hill Notation) C22H29FO5
Grade Ph Eur
Pharmacopeia testing & handling conforms to Pharmacopeia
Gene Information human ... ABCB1(5243), CYP3A4(1576), IL4(3565), IL5(3567), NR3C1(2908)mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126), Ptgs2(19225), Tnf(21926)rat ... Ar(24208), Nr3c1(24413), Tnf(24835)
Melting Point 262-264 °C(lit.)
GHS Pictograms GHS07
GHS Pictograms GHS08
GHS Signal Word Danger
GHS Hazard statements H315-H317-H319-H334-H335
European Hazard Symbols Harmful Harmful (Xn)
MSDS Link Download
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
GHS Precautionary statements P261-P280-P305 + P351 + P338-P342 + P311
Risk Statements 36/37/38-42/43
RTECS TU3980000
Safety Statements 22-26-36/37-45
German water hazard class 2

DETAILS

Description (English)
Biochem/physiol Actions
Glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase.
Description (简体中文)
Biochem/physiol Actions
糖皮质素抗炎剂。调控 T 细胞的存活、生长和分化。抑制一氧化氮合酶的诱导作用。

REFERENCES