Cyclophosphamide monohydrate

• Catalog No.: 29875
• CAS Number: 6055-19-2
• M. F.: C7H17Cl2N2O3P
• M. W.: 279.101241

SYNONYMS

• Title: 环磷酰胺 一水合物
• IUPAC name: 2-[bis(2-chloroethyl)amino]-1,3,2λ^5-oxazaphosphinan-2-one hydrate
• IUPAC Traditional name: cyclophosphamide hydrate
• Synonyms: 2-[双(2-氯乙基)氨基]四氢-2H-1,3,2-噁磷-2-氧化物; Cytoxan; 2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide

DATABASE IDS

• EC Number: 200-015-4
• MDL Number: MFCD00149395
• Beilstein Number: 4678992
• CAS Number: 6055-19-2

PROPERTIES

• Empirical Formula (Hill Notation): C7H15Cl2N2O2P · H2O
• Flash Point: 113 °C
• Flash Point: 235.4 °F
• Melting Point: 49-51 °C(lit.)
• Solubility: H2O: soluble0.1 g/mL, clear, colorless
• GHS Signal Word: Danger
• GHS Hazard statements: H301-H350
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P201-P301 + P310-P308 + P313
• RID/ADR: UN 3464 6.1/PG 3
• Risk Statements: 45-25
• RTECS: RP6157750
• Safety Statements: 53-45
• Storage Temperature: 2-8°C
• Hazard Class: 6.1
• UN Number: 3464
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Cyclophosphamide is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity.

Description (简体中文)

Biochem/physiol Actions
环磷酰胺是一种广泛用于癌症化疗的具有细胞毒性的氮芥衍生物。它可与 DNA 交联、导致链断裂并诱导突变。其临床活性与乙醛脱氢酶 1 (ALDH1) 的活性降低相关。