(±)-Miconazole nitrate salt

• Catalog No.: PHR1163
• CAS Number: 22832-87-7
• M. F.: C18H15Cl4N3O4
• M. W.: 479.1414

SYNONYMS

• IUPAC name: 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole; nitric acid
• IUPAC Traditional name: acid, nitric; miconazole
• Synonyms: 1-(2,4-Dichloro-β-[(2,4-dichlorobenzyl)oxy]phenethyl)imidazole

DATABASE IDS

• MDL Number: MFCD00058161
• EC Number: 245-256-6
• CAS Number: 22832-87-7

PROPERTIES

• Empirical Formula (Hill Notation): C18H14Cl4N2O · HNO3
• Grade: certified reference material
• Packaging: pkg of 1 g
• Pharmacopeia Traceability: traceable to BP 253
• Pharmacopeia Traceability: traceable to PhEur M1900000
• Pharmacopeia Traceability: traceable to USP 1443500
• GHS Signal Word: Warning
• GHS Hazard statements: H302-H317
• European Hazard Symbols: Harmful (Xn)
• GHS Precautionary statements: P280
• Risk Statements: 22-43
• Safety Statements: 36/37
• Storage Temperature: room temp
• German water hazard class: 3

DETAILS

Description (English)

General description
This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO Guide 34.
Other Notes
Values of analytes vary lot to lot.
Biochem/physiol Actions
Miconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary for ergosterol biosynthesis. The inhibition of ergosterol results in increased cellular permeability causing leakage of cellular contents. Miconazole may also inhibit endogenous respiration, interact with phospholipids in the cell membrane, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and interfere with triglyceride and phospholipid biosynthesis.

Description (简体中文)

General description
This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO Guide 34.
Other Notes
Values of analytes vary lot to lot.
Biochem/physiol Actions
Miconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary for ergosterol biosynthesis. The inhibition of ergosterol results in increased cellular permeability causing leakage of cellular contents. Miconazole may also inhibit endogenous respiration, interact with phospholipids in the cell membrane, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and interfere with triglyceride and phospholipid biosynthesis.