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(±)-Miconazole nitrate salt_Molecular_structure_CAS_22832-87-7)
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(±)-Miconazole nitrate salt

Catalog No. PHR1163 Name Sigma Aldrich
CAS Number 22832-87-7 Website http://www.sigmaaldrich.com
M. F. C18H15Cl4N3O4 Telephone 1-800-521-8956
M. W. 479.1414 Fax
Purity Email
Storage Chembase ID: 72827

SYNONYMS

IUPAC name
1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole; nitric acid
IUPAC Traditional name
acid, nitric; miconazole
Synonyms
1-(2,4-Dichloro-β-[(2,4-dichlorobenzyl)oxy]phenethyl)imidazole

DATABASE IDS

MDL Number MFCD00058161
EC Number 245-256-6
CAS Number 22832-87-7

PROPERTIES

Empirical Formula (Hill Notation) C18H14Cl4N2O · HNO3
Grade certified reference material
Packaging pkg of 1 g
Pharmacopeia Traceability traceable to BP 253
Pharmacopeia Traceability traceable to PhEur M1900000
Pharmacopeia Traceability traceable to USP 1443500
GHS Pictograms GHS07
GHS Signal Word Warning
GHS Hazard statements H302-H317
European Hazard Symbols Harmful Harmful (Xn)
MSDS Link Download
GHS Precautionary statements P280
Risk Statements 22-43
Safety Statements 36/37
Storage Temperature room temp
German water hazard class 3

DETAILS

Description (English)
General description
This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO Guide 34.
Other Notes
Values of analytes vary lot to lot.
Biochem/physiol Actions
Miconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary for ergosterol biosynthesis. The inhibition of ergosterol results in increased cellular permeability causing leakage of cellular contents. Miconazole may also inhibit endogenous respiration, interact with phospholipids in the cell membrane, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and interfere with triglyceride and phospholipid biosynthesis.
Description (简体中文)
General description
This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO Guide 34.
Other Notes
Values of analytes vary lot to lot.
Biochem/physiol Actions
Miconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary for ergosterol biosynthesis. The inhibition of ergosterol results in increased cellular permeability causing leakage of cellular contents. Miconazole may also inhibit endogenous respiration, interact with phospholipids in the cell membrane, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and interfere with triglyceride and phospholipid biosynthesis.

REFERENCES