Withanolide A

• Catalog No.: 74776
• CAS Number: 32911-62-9
• M. F.: C28H38O6
• M. W.: 470.59772
• Purity: ≥95.0% (HPLC)

SYNONYMS

• IUPAC name: (1S,2S,4S,5R,10R,11S,14S,15S,18S)-15-[(1R)-1-[(2R)-4,5-dimethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl]-1-hydroxyethyl]-5-hydroxy-10,14-dimethyl-3-oxapentacyclo[9.7.0.0^2,^4.0^5,^1^0.0^1^4,^1^8]octadec-7-en-9-one
• IUPAC Traditional name: (1S,2S,4S,5R,10R,11S,14S,15S,18S)-15-[(1R)-1-[(2R)-4,5-dimethyl-6-oxo-2,3-dihydropyran-2-yl]-1-hydroxyethyl]-5-hydroxy-10,14-dimethyl-3-oxapentacyclo[9.7.0.0^2,^4.0^5,^1^0.0^1^4,^1^8]octadec-7-en-9-one
• Synonyms: (5α,6α,7α,22R)-6,7-Epoxy-5,20,22-trihydroxy-1-oxo-ergosta-2,24-dien-26-oic acid δ-lactone

DATABASE IDS

• CAS Number: 32911-62-9
• MDL Number: MFCD07779143

PROPERTIES

• Empirical Formula (Hill Notation): C28H38O6
• Grade: analytical standard
• Purity: ≥95.0% (HPLC)
• Shelf Life: (limited shelf life, expiry date on the label)
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
C28-steroidal lactone that can induce nerve development and improve nervous system function. Potential therapeutic for neurologic disorders like Alzheimer’s and Parkinson’s disease.1 In primary rat cortical neurons, withanolide A significantly up-regulated IDE levels, a prominent enzyme involved in degrading amyloid β protein, which may help to clear excess amyloid β protein from an Alzheimer′s-inflicted brain.2

Description (简体中文)

Biochem/physiol Actions
C28-steroidal lactone that can induce nerve development and improve nervous system function. Potential therapeutic for neurologic disorders like Alzheimer’s and Parkinson’s disease.1 In primary rat cortical neurons, withanolide A significantly up-regulated IDE levels, a prominent enzyme involved in degrading amyloid β protein, which may help to clear excess amyloid β protein from an Alzheimer′s-inflicted brain.2