Cyclosporin A

• Catalog No.: 32425
• CAS Number: 59865-13-3
• M. F.: C62H111N11O12
• M. W.: 1202.61124

SYNONYMS

• Title: 环孢菌素 A
• IUPAC name: (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(1R,2R)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecone
• IUPAC Traditional name: (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(1R,2R)-1-hydroxy-2-methylhex-4-en-1-yl]-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecone
• Synonyms: Cyclosporine; 抗生素 S 7481F1; 环孢霉素; Antibiotic S 7481F1

DATABASE IDS

• Beilstein Number: 3647785
• CAS Number: 59865-13-3
• MDL Number: MFCD00274558

PROPERTIES

• Empirical Formula (Hill Notation): C62H111N11O12
• Grade: VETRANAL™, analytical standard
• GHS Signal Word: Danger
• GHS Hazard statements: H302-H350-H360
• European Hazard Symbols: Toxic (T)
• GHS Precautionary statements: P201-P308 + P313
• Risk Statements: 45-60-22
• RTECS: GZ4120000
• Safety Statements: 53-45
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A-cyclophilin complex that inhibits calcineurin (protein phosphatase 2B). Inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα. Can block cytochrome c release from mitochondria.
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Description (简体中文)

Biochem/physiol Actions
具有强效免疫抑制性的真菌代谢物。它通过形成抑制钙调磷酸酶（蛋白磷酸酶 2B）的环孢菌素 A-亲环蛋白络合物来抑制 T 细胞受体信号转导通路。抑制通过白介素 1α、脂多糖和TNFα 诱导的一氧化氮合成。能够阻断细胞色素 c 从线粒体的释放。
法律信息
VETRANAL 商标 Sigma-Aldrich Co. LLC