Klebsiella Selective Supplement

• Catalog No.: 15821
• M. F.: C17H18N2O6S
• M. W.: 378.39962

SYNONYMS

• Title: 克雷伯氏菌选择性添加剂
• IUPAC name: (2S,5R,6R)-6-(2-carboxy-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
• IUPAC Traditional name: carbenicillin
• Synonyms: Carbenicillin; α-Carboxybenzylpenicillin solution; 羧苄青霉素; α-Carboxybenzylpenicillin 溶液

DATABASE IDS

• EC Number: 225-171-0
• MDL Number: MFCD00242604

PROPERTIES

• Empirical Formula (Hill Notation): C17H18N2O6S
• Grade: for microbiology
• Shelf Life: (limited shelf life, expiry date on the label)
• GHS Signal Word: Danger
• GHS Hazard statements: H317-H334
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS Precautionary statements: P261-P280-P342 + P311
• Risk Statements: 42/43
• RTECS: ON9104700
• Safety Statements: 22-36/37-45
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Components
(per vial, sufficient for 500 ml medium)Carbenicillin 25 mg
Application
For selective isolation and detection of Klebsiella species.
Biochem/physiol Actions
The antibiotic carbenicillin, an ampicillin analog, is a commonly used selection agent that binds and inhibits enzymes involved in the synthesis of the bacterial cell wall. It is active against most isolates of Pseudomonas aerogenosa and certain indole-positive Proteus strains that are resistant to ampicillin. The gene conferring resistance to ampicillin and its analogs, ampr, codes for the enzyme β-lactamase. Carbenicillin is less sensitive to β-lactamase than ampicillin. In addition it has a superior stability at low pH. Experiments have shown that the use of carbenicillin in place of ampicillin helps prevent overgrowth of satellite colonies. Effective concentration: 50 to 100 μg/ml.
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. 15821.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Description (简体中文)

Components
（每瓶，足够用于 500mL 培养基） 羧苄青霉素 25mg
Application
用于选择性分离和检测克雷伯氏菌。
Biochem/physiol Actions
羧苄青霉素是氨苄青霉素的类似物，是一种常用的选择剂，它可以结合并抑制细菌细胞壁合成中涉及到的酶。它对耐氨苄青霉素的大多数铜绿假单胞菌分离株以及某些吲哚阳性变形杆菌?均有效。氨苄青霉素及其类似物抗性基因 ampr 编码 β-内酰胺酶。羧苄青霉素比氨苄青霉素对 β-内酰胺酶的敏感性更弱。此外它在低 pH 下具有优异的稳定性。实验表明，用羧苄青霉素替代氨苄青霉素有助于防止卫星菌落的过度生长。有效浓度：50 至 100μg/mL。
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. 15821.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.