Diisopropyl azodicarboxylate

• Catalog No.: 11626
• CAS Number: 2446-83-5
• M. F.: C8H14N2O4
• M. W.: 202.20776
• Purity: ≥94% (GC)

SYNONYMS

• Title: 偶氮二甲酸二异丙酯
• IUPAC name: N-{[(propan-2-yloxy)carbonyl]imino}(propan-2-yloxy)formamide
• IUPAC Traditional name: diisopropyl azodicarboxylate
• Synonyms: Diisopropyl azodiformate; DIAD

DATABASE IDS

• EC Number: 219-502-8
• PubChem SID: 24847276
• MDL Number: MFCD00008875
• Beilstein Number: 1912326
• CAS Number: 2446-83-5

PROPERTIES

• Grade: technical
• Linear Formula: (CH3)2CHOOCN=NCOOCH(CH3)2
• Purity: ≥94% (GC)
• Boiling Point: 75 °C/0.25 mmHg(lit.)
• Density: 1.027 g/mL at 25 °C(lit.)
• Flash Point: 106 °C
• Flash Point: 223 °F
• Refractive Index: n20/D 1.420(lit.)
• Refractive Index: n20/D 1.420
• European Hazard Symbols: Irritant (Xi)
• European Hazard Symbols: Nature polluting (N)
• RID/ADR: UN 3082 9/PG 3
• Risk Statements: 36/38-51/53
• Safety Statements: 26-60
• Storage Temperature: 2-8°C
• Hazard Class: 9
• UN Number: 3082
• Packing Group: 3
• German water hazard class: 1

DETAILS

Description (English)

Other Notes
Reagent used in the Mitsunobu reaction, reviews8,9
Application
Reactant for preparation of:
• Chromenes resembling classical cannabinoids1
• MK-3281 inhibitor of the hepatitis C virus NS5B polymerase2
• Norbornene-based guanidine-rich polymers as mimcs of cell-penetrating peptides (CPP)3
• Analogues of the Pseudomonas aeruginosa quorum-sensing molecule N-(3-Oxododecanoyl)-l-homoserine lactone with immunosuppressive but non-LasR-inducing properties4
• Acceptor-donor-acceptor organic dyes for dye-sensitized solar cells5
• 1,3-dioxane-2-carboxylic acid derivatives as PPARα/γ dual agonists6
• Hydrazinophosphonates and hydrazinobisphosphonates via Mitsunobu and Arbuzov-type multicomponent application of the Morrison-Brunn-Huisgen betaine7

Description (简体中文)

Other Notes
用于 Mitsunobu 反应的试剂，综述8,9
Application
Reactant for preparation of:
• Chromenes resembling classical cannabinoids1
• MK-3281 inhibitor of the hepatitis C virus NS5B polymerase2
• Norbornene-based guanidine-rich polymers as mimcs of cell-penetrating peptides (CPP)3
• Analogues of the Pseudomonas aeruginosa quorum-sensing molecule N-(3-Oxododecanoyl)-l-homoserine lactone with immunosuppressive but non-LasR-inducing properties4
• Acceptor-donor-acceptor organic dyes for dye-sensitized solar cells5
• 1,3-dioxane-2-carboxylic acid derivatives as PPARα/γ dual agonists6
• Hydrazinophosphonates and hydrazinobisphosphonates via Mitsunobu and Arbuzov-type multicomponent application of the Morrison-Brunn-Huisgen betaine7