N-(2-Aminoethyl)-5-isoquinolinesulfonamide hydrochloride

• Catalog No.: 06725
• CAS Number: 116970-50-4
• M. F.: C11H14ClN3O2S
• M. W.: 287.76576
• Purity: ≥97.0% (HPLC)

SYNONYMS

• IUPAC name: N-(2-aminoethyl)isoquinoline-5-sulfonamide hydrochloride
• IUPAC Traditional name: N-(2-aminoethyl)isoquinoline-5-sulfonamide hydrochloride
• Synonyms: H-9

DATABASE IDS

• Beilstein Number: 6548866
• CAS Number: 116970-50-4
• MDL Number: MFCD00083242

PROPERTIES

• Empirical Formula (Hill Notation): C11H13N3O2S · HCl
• Purity: ≥97.0% (HPLC)
• Solubility: methanol: soluble1 mg/mL, clear, colorless
• GHS Signal Word: Warning
• GHS Hazard statements: H302-H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• RTECS: NX4897000
• Safety Statements: 26-36
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Selective casein kinase 1 inhibitor1. Potent inhibitor of histamine release from human basophils when induced by phorbol ester or DiC8, but not when induced by anti-IgE, fMLP (formyl-Met-Leu-Phe) and calcium ionophore A23187.2 This implicates divergent pathways of basophil activation.

Description (简体中文)

Biochem/physiol Actions
Selective casein kinase 1 inhibitor1. Potent inhibitor of histamine release from human basophils when induced by phorbol ester or DiC8, but not when induced by anti-IgE, fMLP (formyl-Met-Leu-Phe) and calcium ionophore A23187.2 This implicates divergent pathways of basophil activation.