Diethyl isocyanomethylphosphonate

• Catalog No.: 58833
• CAS Number: 41003-94-5
• M. F.: C6H12NO3P
• M. W.: 177.138141
• Purity: ≥97.0% (GC)

SYNONYMS

• Title: 异腈甲基膦酸二乙酯
• IUPAC name: diethyl (isocyanomethyl)phosphonate
• IUPAC Traditional name: diethyl isocyanomethylphosphonate
• Synonyms: Isocyanomethylphosphonic acid diethyl ester

DATABASE IDS

• CAS Number: 41003-94-5
• PubChem SID: 24881211
• Beilstein Number: 4674920
• MDL Number: MFCD00042951

PROPERTIES

• Grade: purum
• Linear Formula: CNCH2P(O)(OC2H5)2
• Purity: ≥97.0% (GC)
• Boiling Point: 84-87 °C/0.1 mmHg(lit.)
• Density: 1.105 g/mL at 25 °C(lit.)
• Flash Point: 113 °C
• Flash Point: 235.4 °F
• Refractive Index: n20/D 1.433(lit.)
• GHS Signal Word: Warning
• GHS Hazard statements: H302 + H312 + H332-H315-H319-H335
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
• GHS Precautionary statements: P261-P280-P305 + P351 + P338
• Risk Statements: 20/21/22-36/37/38
• Safety Statements: 26-36
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Other Notes
Prep. of phosphonic acid analogs of amino acids6,7,8; Synthesis of aldehydes from carbonyl compounds9,10
Application
Reactant for:
• Copper-catalyzed cycloaddition reactions1
• Preparation of orally bioavailable diamide prodrugs that lower glucose in diabetic animals through inhibition of fructose-1,6-bisphosphatase2
• Synthesis of sterol analogs as antifungal agents against plant pathogens3
• Asymmetric synthesis of steroidal 2,5-diketopiperazines prepared via isocyanide chemistry based on stereoselective Ugi four component condensation and subsequent cyclocondensation reactions4
• The Passerini reaction5

Description (简体中文)

Other Notes
制备 α-氨基酸的膦酸类似物6,7,8；由羰基化合物合成醛9,10
Application
Reactant for:
• Copper-catalyzed cycloaddition reactions1
• Preparation of orally bioavailable diamide prodrugs that lower glucose in diabetic animals through inhibition of fructose-1,6-bisphosphatase2
• Synthesis of sterol analogs as antifungal agents against plant pathogens3
• Asymmetric synthesis of steroidal 2,5-diketopiperazines prepared via isocyanide chemistry based on stereoselective Ugi four component condensation and subsequent cyclocondensation reactions4
• The Passerini reaction5