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Chlorpromazine hydrochloride_Molecular_structure_CAS_69-09-0)
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Chlorpromazine hydrochloride

Catalog No. 26060 Name Sigma Aldrich
CAS Number 69-09-0 Website http://www.sigmaaldrich.com
M. F. C17H20Cl2N2S Telephone 1-800-521-8956
M. W. 355.3251 Fax
Purity ≥95.0% (AT) Email
Storage Chembase ID: 53503

SYNONYMS

Title
氯丙嗪 盐酸盐
IUPAC name
[3-(2-chloro-10H-phenothiazin-10-yl)propyl]dimethylamine hydrochloride
IUPAC Traditional name
chlorpromazine hydrochloride
Synonyms
氯普马嗪
2-Chloro-10-(3-dimethylaminopropyl)phenothiazine hydrochloride
Largactil
2-氯-10-(3-二甲氨基丙基)吩噻嗪 盐酸盐
CPZ

DATABASE IDS

Beilstein Number 3779989
EC Number 200-701-3
MDL Number MFCD00012654
CAS Number 69-09-0

PROPERTIES

Empirical Formula (Hill Notation) C17H19ClN2S · HCl
Ignition Residue ≤0.1%
Purity ≥95.0% (AT)
GHS Pictograms GHS06
GHS Signal Word Danger
GHS Hazard statements H301-H330
European Hazard Symbols Highly toxic Highly toxic (T+)
MSDS Link Download
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
GHS Precautionary statements P260-P284-P301 + P310-P310
RID/ADR UN 2811 6.1/PG 1
Risk Statements 25-26
RTECS SO1750000
Safety Statements 28-36/37-45
Hazard Class 6.1
UN Number 2811
Packing Group 1
German water hazard class 3

DETAILS

Description (English)
Application
Substitute for benzidine, o-dianisidine, and o-tolidine in the determination of microquantities of hemoglobin and peroxidase.
Biochem/physiol Actions
Chlorpromazine demonstrates cytotoxic and antiproliferative activity against leukemic cells, but does not affect the viability of normal lymphocytes.
Phenothiazine antipsychotic; D2 dopamine receptor antagonist, H1 histamine receptor antagonist; inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase and nitric oxide synthase.
Other Notes
Uncouples and inhibits oxidative phoshorylation at 10-3-10-4 M1,2; Interaction of phenothiazine antipsychotics with calmodulin3
Description (简体中文)
Application
在血红蛋白和过氧化物酶的微量测定中替代联苯胺、邻联茴香胺和邻联甲苯胺。
Biochem/physiol Actions
吩噻嗪类抗精神病药;D2 多巴胺受体拮抗剂,H1 组胺受体拮抗剂;抑制钙调蛋白依赖性环核苷酸磷酸二酯酶和一氧化氮合成酶的活化。
氯丙嗪表现出对白血病细胞的细胞毒性和抗增殖活性,但是不会影响正常淋巴细胞的活力。
Other Notes
Uncouples and inhibits oxidative phoshorylation at 10-3-10-4 M1,2; Interaction of phenothiazine antipsychotics with calmodulin3

REFERENCES