γ-Butyrolactone

• Catalog No.: 20740
• CAS Number: 96-48-0
• M. F.: C4H6O2
• M. W.: 86.08924
• Purity: ≥99.0% (GC)

SYNONYMS

• Title: γ-丁内酯
• IUPAC name: oxolan-2-one
• IUPAC Traditional name: butyrolactone
• Synonyms: γ-羟基丁酸内酯; 4-Hydroxybutyric acid lactone; GBL; γ-Hydroxybutyric acid lactone; 4-羟基丁酸内酯

DATABASE IDS

• MDL Number: MFCD00005386
• Beilstein Number: 105248
• CAS Number: 96-48-0
• EC Number: 202-509-5

PROPERTIES

• Empirical Formula (Hill Notation): C4H6O2
• Grade: puriss.
• Purity: ≥99.0% (GC)
• Auto Ignition Point: 851 °F
• Boiling Point: 204-205 °C(lit.)
• Density: 1.12 g/mL at 25 °C(lit.)
• Flash Point: 98 °C
• Flash Point: 208.4 °F
• Melting Point: -45 °C(lit.)
• Refractive Index: n20/D 1.436(lit.)
• Refractive Index: n20/D 1.437
• Vapor Density: 3 (vs air)
• Vapor Pressure: 1.5 mmHg ( 20 °C)
• Explode Limits: 16 %
• GHS Signal Word: Danger
• GHS Hazard statements: H302-H318-H336
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
• GHS Precautionary statements: P261-P280-P305 + P351 + P338
• Risk Statements: 22-41-67
• RTECS: LU3500000
• Safety Statements: 26-39
• German water hazard class: 1

DETAILS

Description (English)

Biochem/physiol Actions
Precursor of γ-hydroxybutyric acid (GHB). It blocks dopamine release by blocking impulse flow in dopaminergic neurons. Pretreatment with γ-butyrolactone allows detection of autoreceptor-induced dopamine release.

Description (简体中文)

Biochem/physiol Actions
γ-羟基丁酸 (GHB) 的前体。它可通过阻断多巴胺能神经元中的脉冲流，抑制多巴胺的释放。用 γ-丁内酯预处理可检测自身受体诱导的多巴胺释放。