Mettler-Toledo® Calibration substance ME 18872, Caffeine

• Catalog No.: 75035
• CAS Number: 58-08-2
• M. F.: C8H10N4O2
• M. W.: 194.1906

SYNONYMS

• Title: Mettler-Toledo® 校准物质 ME 18872，咖啡因
• IUPAC name: 1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
• IUPAC Traditional name: caffeine
• Synonyms: Caffeine; 1,3,7-Trimethylxanthine; 1,3,7-三甲基黄嘌呤; 咖啡因

DATABASE IDS

• PubChem SID: 24886771
• CAS Number: 58-08-2
• EC Number: 200-362-1
• MDL Number: MFCD00005758
• Beilstein Number: 17705

PROPERTIES

• Empirical Formula (Hill Notation): C8H10N4O2
• Grade: analytical standard
• Grade: for the calibration of the thermosystem 900
• Quality: traceable to primary standards (LGC)
• Shelf Life: (limited shelf life, expiry date on the certificate and label)
• Gene Information: human ... ADORA1(134), ADORA2B(136), ADORA3(140), PDE4B(5142)mouse ... Adora2b(11541)rat ... Adora1(29290), Adora2a(25369)
• Melting Point: 234-236.5 °C(lit.)
• GHS Signal Word: Warning
• GHS Hazard statements: H302
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• RID/ADR: UN 1544 6.1/PG 3
• Risk Statements: 22
• RTECS: EV6475000
• Hazard Class: 6.1
• UN Number: 1544
• Packing Group: 3
• German water hazard class: 1

DETAILS

Description (English)

Biochem/physiol Actions
A central nervous system stimulant believed to act through adenosine receptors and monoamine neurotransmitters. It is an adenosine receptor antagonist and adenosine 3′,5′-cyclic monophosphate (cAMP) phosphodiesterase inhibitor. Thus, levels of cAMP increase in cells following treatment with caffeine. It has been reported to affect cellular calcium levels, releasing calcium from intracellular stores. It overrides the cell cycle effects of various chemicals such as protease inhibitors, preventing apoptosis; and it has been shown to inhibit cellular DNA repair mechanisms.
Legal Information
Mettler-Toledo is a registered trademark of Mettler-Toledo, Inc.

Description (简体中文)

Biochem/physiol Actions
一种据信是通过腺苷受体和单胺类神经递质发挥作用的中枢神经系统兴奋剂。它为腺苷受体拮抗剂和腺苷3′，5′-环单磷酸 (cAMP) 磷酸二酯酶抑制剂。因此，在用咖啡因处理后，细胞内 cAMP 的水平将升高。据报道，它会影响细胞的钙水平，从而使细胞内的钙离子外流。它会使多种化学物质(例如蛋白酶抑制剂)的细胞周期效应无效，从而防止细胞凋亡;同时，还发现它可以抑制细胞的 DNA 修复机制。
法律信息
Mettler-Toledo 注册商标 Mettler-Toledo, Inc.