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Adenosine 3′,5′-cyclic monophosphate_Molecular_structure_CAS_60-92-4)
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Adenosine 3′,5′-cyclic monophosphate

Catalog No. 01895 Name Sigma Aldrich
CAS Number 60-92-4 Website http://www.sigmaaldrich.com
M. F. C10H12N5O6P Telephone 1-800-521-8956
M. W. 329.205941 Fax
Purity ≥99.0% (HPLC) Email
Storage Chembase ID: 102121

SYNONYMS

Title
腺苷-3′,5′-环单磷酸
IUPAC name
(4aR,6R,7R,7aS)-6-(6-amino-9H-purin-9-yl)-2,7-dihydroxy-hexahydro-1,3,5,2λ5-furo[3,2-d][1,3,2λ5]dioxaphosphinin-2-one
IUPAC Traditional name
cyclic adenosine monophosphate
Synonyms
环化腺苷酸
cAMP
Adenosine 3′,5′-cyclophosphate
3′,5′-Cyclic AMP
腺苷环磷酸酯

DATABASE IDS

CAS Number 60-92-4
Beilstein Number 52645
EC Number 200-492-9
MDL Number MFCD00005845

PROPERTIES

Empirical Formula (Hill Notation) C10H12N5O6P
Impurities ≤5% water
Purity ≥99.0% (HPLC)
Melting Point 260 °C (dec.)(lit.)
Optical Rotation [α]20/D -54±2°, c = 0.7% in H2O
MSDS Link Download
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RTECS AU7357600
Storage Temperature 2-8°C
German water hazard class 3

DETAILS

Description (English)
Other Notes
Intracellular messenger. Binding to cyclic AMP-dependent protein kinase1
Biochem/physiol Actions
Naturally-occurring activator of cyclic-AMP-dependent protein kinase (PKA). cAMP is an important second messenger that is linked in many systems to neurotransmitter- or hormone-induced receptor stimulation. The cAMP/PKA signaling pathway has been shown to inhibit cell proliferation, induce differentiation and lead to apoptosis.
Description (简体中文)
Other Notes
Intracellular messenger. Binding to cyclic AMP-dependent protein kinase1
Biochem/physiol Actions
环化腺苷酸依赖性蛋白激酶 (PKA) 的自然活化剂。cAMP 是一种重要的第二信使,并且在很多系统中与神经递质或激素诱导的受体激活相关。已有显示,cAMP/PKA 信号通路可抑制细胞增殖,诱导分化并导致细胞凋亡。

REFERENCES