Adenosine 3′,5′-cyclic monophosphate

• Catalog No.: 01895
• CAS Number: 60-92-4
• M. F.: C10H12N5O6P
• M. W.: 329.205941
• Purity: ≥99.0% (HPLC)

SYNONYMS

• Title: 腺苷-3′,5′-环单磷酸
• IUPAC name: (4aR,6R,7R,7aS)-6-(6-amino-9H-purin-9-yl)-2,7-dihydroxy-hexahydro-1,3,5,2λ^5-furo[3,2-d][1,3,2λ^5]dioxaphosphinin-2-one
• IUPAC Traditional name: cyclic adenosine monophosphate
• Synonyms: 环化腺苷酸; cAMP; Adenosine 3′,5′-cyclophosphate; 3′,5′-Cyclic AMP; 腺苷环磷酸酯

DATABASE IDS

• CAS Number: 60-92-4
• Beilstein Number: 52645
• EC Number: 200-492-9
• MDL Number: MFCD00005845

PROPERTIES

• Empirical Formula (Hill Notation): C10H12N5O6P
• Impurities: ≤5% water
• Purity: ≥99.0% (HPLC)
• Melting Point: 260 °C (dec.)(lit.)
• Optical Rotation: [α]20/D -54±2°, c = 0.7% in H2O
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS: AU7357600
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Other Notes
Intracellular messenger. Binding to cyclic AMP-dependent protein kinase1
Biochem/physiol Actions
Naturally-occurring activator of cyclic-AMP-dependent protein kinase (PKA). cAMP is an important second messenger that is linked in many systems to neurotransmitter- or hormone-induced receptor stimulation. The cAMP/PKA signaling pathway has been shown to inhibit cell proliferation, induce differentiation and lead to apoptosis.

Description (简体中文)

Other Notes
Intracellular messenger. Binding to cyclic AMP-dependent protein kinase1
Biochem/physiol Actions
环化腺苷酸依赖性蛋白激酶 (PKA) 的自然活化剂。cAMP 是一种重要的第二信使，并且在很多系统中与神经递质或激素诱导的受体激活相关。已有显示，cAMP/PKA 信号通路可抑制细胞增殖，诱导分化并导致细胞凋亡。