5-Fluoro-2′-deoxyuridine

• Catalog No.: 46875
• CAS Number: 50-91-9
• M. F.: C9H11FN2O5
• M. W.: 246.1924432
• Purity: ≥98.0% (HPLC)

SYNONYMS

• IUPAC name: 5-fluoro-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione
• IUPAC Traditional name: floxuridine
• Synonyms: 2′-Deoxy-5-fluorouridine; FUDR; Floxuridine

DATABASE IDS

• EC Number: 200-072-5
• MDL Number: MFCD00006530
• CAS Number: 50-91-9
• Beilstein Number: 90221

PROPERTIES

• Empirical Formula (Hill Notation): C9H11FN2O5
• Purity: ≥98.0% (HPLC)
• Melting Point: 148 °C(lit.)
• Melting Point: 148-150 °C
• Optical Rotation: [α]20/D +38±1°, c = 1% in H2O
• GHS Signal Word: Danger
• GHS Hazard statements: H301
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS Precautionary statements: P301 + P310
• RID/ADR: UN 2811 6.1/PG 3
• Risk Statements: 22
• RTECS: YU7525000
• Safety Statements: 22-36
• Storage Temperature: 2-8°C
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Antineoplastic drug that acts as a potent inhibitor of thymidylate synthetase1 Resistance to FUdR can develop in cancer cell cultures, among other means, by low-level Mycoplasma infection.2
Other Notes
Inhibits DNA synthesis by prior inhibition of thymidylate synthetase3

Description (简体中文)

Biochem/physiol Actions
Antineoplastic drug that acts as a potent inhibitor of thymidylate synthetase1 Resistance to FUdR can develop in cancer cell cultures, among other means, by low-level Mycoplasma infection.2
Other Notes
Inhibits DNA synthesis by prior inhibition of thymidylate synthetase3