Streptomycin sulfate salt

• Catalog No.: 85880
• CAS Number: 3810-74-0
• M. F.: C42H84N14O36S3
• M. W.: 1457.38356
• Purity: ~95% (T)

SYNONYMS

• Title: 链霉素 硫酸盐
• IUPAC name: bis(1-[(1R,2S,3S,4R,5S,6S)-3-carbamimidamido-6-{[(2R,3R,4R,5S)-3-{[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy}-4-formyl-4-hydroxy-5-methyloxolan-2-yl]oxy}-2,4,5-trihydroxycyclohexyl]guanidine); tris(sulfuric acid)
• IUPAC Traditional name: bis(1-[(1R,2S,3S,4R,5S,6S)-3-carbamimidamido-6-{[(2R,3R,4R,5S)-3-{[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy}-4-formyl-4-hydroxy-5-methyloxolan-2-yl]oxy}-2,4,5-trihydroxycyclohexyl]guanidine); tris(sulfuric acid)

DATABASE IDS

• CAS Number: 3810-74-0
• Beilstein Number: 3894995
• MDL Number: MFCD00037023
• EC Number: 223-286-0

PROPERTIES

• Linear Formula: C21H39N7O12 · 1.5 H2SO4
• Loss on Drying: ≤5% loss on drying
• Purity: ~95% (T)
• Solubility: H2O: soluble0.1 g/mL, clear
• GHS Signal Word: Warning
• GHS Hazard statements: H302-H361
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS Precautionary statements: P281
• Risk Statements: 63-22
• RTECS: WK4990000
• Safety Statements: 36/37
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Mode of Action: Inhibits prokaryote protein synthesis. Binds to S12 protein of 30S ribosomal subunit, preventing the transition from initiation complex to chain-elongating ribosome, causing miscoding or inhibiting initiation. Mode of Resistance: Mutation in rpsL (gene for S12 ribosomal protein) prevents binding of streptomycin to ribosome. Aminoglycoside phosphotransferase also inactivates.Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
Other Notes
Inhibits initiation and causes misreading of mRNA in protein synthesis1; Removal of DNA in cloning and expression of avidin in E. coli2.

Description (简体中文)

Biochem/physiol Actions
Mode of Action: Inhibits prokaryote protein synthesis. Binds to S12 protein of 30S ribosomal subunit, preventing the transition from initiation complex to chain-elongating ribosome, causing miscoding or inhibiting initiation. Mode of Resistance: Mutation in rpsL (gene for S12 ribosomal protein) prevents binding of streptomycin to ribosome. Aminoglycoside phosphotransferase also inactivates.Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
Other Notes
在蛋白质合成中抑制启动并导致 mRNA 的误读1；在 E. coli2 中克隆和表达抗生物素蛋白时移除 DNA