Streptozocin

• Catalog No.: 85882
• CAS Number: 18883-66-4
• M. F.: C8H15N3O7
• M. W.: 265.2206
• Purity: ≥98.0% (HPLC)

SYNONYMS

• IUPAC name: 3-methyl-3-nitroso-1-[(2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea
• IUPAC Traditional name: streptozocin
• Synonyms: Streptozotocin; N-(Methylnitrosocarbamoyl)-α-D-glucosamine

DATABASE IDS

• MDL Number: MFCD00006607
• EC Number: 242-646-8
• Beilstein Number: 2060675
• CAS Number: 18883-66-4

PROPERTIES

• Empirical Formula (Hill Notation): C8H15N3O7
• Purity: ≥98.0% (HPLC)
• Melting Point: 121 °C (dec.)(lit.)
• GHS Signal Word: Danger
• GHS Hazard statements: H350
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P201-P308 + P313
• Risk Statements: 45
• RTECS: LZ5775000
• Safety Statements: 53-45
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
An N-nitroso-containing compound that acts as a nitric oxide donor in pancreatic islets; induces death of insulin-secreting cells, producing an animal model of diabetes. Potent DNA methylating agent that induces chromosomal breakage.1 Cytotoxic to neuroendocrine tumor cell lines that express the GLUT2 glucose transporter.

Description (简体中文)

Biochem/physiol Actions
An N-nitroso-containing compound that acts as a nitric oxide donor in pancreatic islets; induces death of insulin-secreting cells, producing an animal model of diabetes. Potent DNA methylating agent that induces chromosomal breakage.1 Cytotoxic to neuroendocrine tumor cell lines that express the GLUT2 glucose transporter.