Retinoic acid

• Catalog No.: 95152
• CAS Number: 302-79-4
• M. F.: C20H28O2
• M. W.: 300.43512
• Purity: ≥98.0% (HPLC)

SYNONYMS

• IUPAC name: 3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid
• IUPAC Traditional name: isotretinoin
• Synonyms: tretinoin; ATRA; all-trans-Retinoic acid; Vitamin A acid

DATABASE IDS

• EC Number: 206-129-0
• MDL Number: MFCD00001551
• CAS Number: 302-79-4
• Beilstein Number: 2057223

PROPERTIES

• Empirical Formula (Hill Notation): C20H28O2
• Ignition Residue: ≤0.1% (as SO4)
• Impurities: ≤0.002% heavy metals
• Loss on Drying: ≤0.5% loss on drying
• Purity: ≥98.0% (HPLC)
• Gene Information: human ... RARA(5914), RARB(5915), RARG(5916)
• Melting Point: 180-181 °C(lit.)
• Melting Point: 182-186 °C
• GHS Signal Word: Warning
• GHS Hazard statements: H302-H411
• European Hazard Symbols: Harmful (Xn)
• European Hazard Symbols: Nature polluting (N)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P273
• Risk Statements: 22-51/53
• RTECS: VH6475000
• Safety Statements: 61
• Storage Temperature: 2-8°C
• German water hazard class: 2

DETAILS

Description (English)

Other Notes
Review: Retinoic acid metabolism1
Unit Definition
1 U corresponds to 1 international U acc. to Ph Eur II, 217 (1983)
Biochem/physiol Actions
all-trans-Retinoic acid (ATRA) is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). The bound RAR and RXR act as transcription factors that regulate the growth and differentiation of both normal and malignant cells. Cytochromes P450 (CYPs) catalyze the 4-hydroxylation of ATRA. Retinoic acid primes embryonic stem cells to become neurons.

Description (简体中文)

Other Notes
Review: Retinoic acid metabolism1
Unit Definition
1 U corresponds to 1 international U acc. to Ph Eur II, 217 (1983)
Biochem/physiol Actions
all-trans-Retinoic acid (ATRA) is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). The bound RAR and RXR act as transcription factors that regulate the growth and differentiation of both normal and malignant cells. Cytochromes P450 (CYPs) catalyze the 4-hydroxylation of ATRA. Retinoic acid primes embryonic stem cells to become neurons.