α-Lobeline hydrochloride

• Catalog No.: 62630
• CAS Number: 134-63-4
• M. F.: C22H28ClNO2
• M. W.: 373.91622
• Purity: ≥98.0% (AT)

SYNONYMS

• Title: α-洛贝林 盐酸盐
• IUPAC name: 2-[(2R,6S)-6-[(2S)-2-hydroxy-2-phenylethyl]-1-methylpiperidin-2-yl]-1-phenylethan-1-one hydrochloride
• IUPAC Traditional name: (-)-lobeline hydrochloride
• Synonyms: 2-[6-(2-羟基-2-苯乙基)-1-甲基-2-呱啶基]-1-苯乙酮 盐酸盐; (-)-洛贝林 盐酸盐; 2-[6-(2-Hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl]-1-phenylethanone hydrochloride; (-)-Lobeline hydrochloride

DATABASE IDS

• EC Number: 205-150-2
• PubChem SID: 24882261
• CAS Number: 134-63-4
• Beilstein Number: 3920196
• MDL Number: MFCD00082455

PROPERTIES

• Empirical Formula (Hill Notation): C22H27NO2 · HCl
• Grade: purum
• Purity: ≥98.0% (AT)
• Melting Point: 178-180 °C
• Optical Rotation: [α]20/D -57±2°, c = 2% in H2O
• GHS Signal Word: Danger
• GHS Hazard statements: H301-H331
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• GHS Precautionary statements: P261-P301 + P310-P311
• RID/ADR: UN 1544 6.1/PG 3
• Risk Statements: 23/25
• RTECS: OJ8490100
• Safety Statements: 36/37/39-45
• Hazard Class: 6.1
• UN Number: 1544
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Agonist at high-affinity neuronal nicotinic acetylcholine receptors; respiratory stimulant. Inhibits synaptosomal accumulation of dopamine by interaction with the tetrabenazine binding site of the vesicular monoamine transporter (VMAT2). Blocks amphetamine-induced dopamine release.

Description (简体中文)

Biochem/physiol Actions
高亲和性神经元烟碱型乙酰胆碱受体激动剂；呼吸兴奋剂。通过与囊泡单胺转运体 (VMAT2) 的四苯喹嗪结合位点相互作用来抑制多巴胺的突触积累。阻断安非他明诱导的多巴胺释放。