8-Bromoadenosine 3′,5′-cyclic monophosphate

• Catalog No.: 16137
• CAS Number: 23583-48-4
• M. F.: C10H11BrN5O6P
• M. W.: 408.102001
• Purity: ≥98.0% (HPLC)

SYNONYMS

• Title: 8-溴腺苷3′,5′-环单磷酸
• IUPAC name: (4aR,6R,7R,7aS)-6-(6-amino-8-bromo-9H-purin-9-yl)-2,7-dihydroxy-hexahydro-1,3,5,2λ^5-furo[3,2-d][1,3,2λ^5]dioxaphosphinin-2-one
• IUPAC Traditional name: 8-Br-cAMP
• Synonyms: 8-Br-cAMP

DATABASE IDS

• MDL Number: MFCD00075580
• Beilstein Number: 591930
• EC Number: 245-760-6
• CAS Number: 23583-48-4

PROPERTIES

• Empirical Formula (Hill Notation): C10H11BrN5O6P
• Impurities: ≤1% water
• Purity: ≥98.0% (HPLC)
• Melting Point: 254 °C (dec.)(lit.)
• Solubility: 0.1 M NaOH: soluble50 mg/mL, clear, faintly yellow or pink
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• German water hazard class: 3

DETAILS

Description (English)

Other Notes
Membrane-permeable cAMP analog.
Cyclic nucleotide analog for studying Ca2+- mediated pathways1,2; Potent activator of protein kinase3
Biochem/physiol Actions
Cell-permeable cAMP analog having greater resistance to hydrolysis by phosphodiesterases than cAMP. Activates protein kinase A, inhibits growth, decreases proliferation, increases differentiation, and induces apoptosis of cultured cells.

Description (简体中文)

Other Notes
膜渗透性 cAMP 类似物。
Cyclic nucleotide analog for studying Ca2+- mediated pathways1,2; Potent activator of protein kinase3
Biochem/physiol Actions
比 cAMP 更抗磷酸二酯酶水解的细胞通透性 cAMP 类似物。激活培养细胞的蛋白激酶 A、抑制生长、减少增殖、增加分化并诱导凋亡。