Cholecalciferol

• Catalog No.: 95230
• CAS Number: 67-97-0
• M. F.: C27H44O
• M. W.: 384.63766
• Purity: ≥99.0% (sum of enantiomers, HPLC)

SYNONYMS

• Title: 胆钙化醇
• IUPAC name: (1S)-3-{2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-octahydro-1H-inden-4-ylidene]ethylidene}-4-methylidenecyclohexan-1-ol
• IUPAC Traditional name: cholecalciferol
• Synonyms: (+)-Vitamin D3; Calciol; Activated 7-dehydrocholesterol; 7-Dehydrocholesterol activated; (+)-维生素 D3; 活化7-脱氢胆固醇; 活化7-脱氢胆甾醇; 胆骨化醇

DATABASE IDS

• EC Number: 200-673-2
• MDL Number: MFCD00078131
• Beilstein Number: 2339331
• CAS Number: 67-97-0

PROPERTIES

• Empirical Formula (Hill Notation): C27H44O
• Purity: ≥99.0% (sum of enantiomers, HPLC)
• Melting Point: 83-86 °C(lit.)
• Melting Point: 83-86 °C
• Optical Rotation: [α]20/D +109±3°, c = 2% in ethanol
• GHS Signal Word: Danger
• GHS Hazard statements: H301-H311-H330-H372
• European Hazard Symbols: Highly toxic (T+)
• Personal Protective Equipment: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P260-P280-P284-P301 + P310-P310
• RID/ADR: UN 2811 6.1/PG 2
• Risk Statements: 24/25-26-48/25
• RTECS: VS2900000
• Safety Statements: 28-36/37-45
• Storage Temperature: 2-8°C
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: 2
• German water hazard class: 2

DETAILS

Description (English)

Other Notes
Review: Vitamin D: Recent advances1
Unit Definition
1 U corresponds to 1 international U according to commentary-DAB, 8th issue, 38 (1981)
Biochem/physiol Actions
Vitamin D acts through a receptor that is a member of the ligand-dependent transcription factor superfamily. Modulates the proliferation and differentiation of both normal and cancer cells. Has antiproliferative and antimetastatic effects on breast, colon, and prostate cancer cells. Activated vitamin D receptors in intestine and bone maintain calcium absorbance and homeostasis.

Description (简体中文)

Other Notes
综述：维生素 D：最新进展1
Unit Definition
根据 commentary-DAB, 8th issue, 38 (1981)，1U 相当于 1 个国际单位
Biochem/physiol Actions
维生素 D 借以发挥作用的受体是配体依赖性转录因子超家族的成员。调控正常细胞和癌细胞的增殖和分化。对乳腺癌、结肠癌和前列腺癌细胞具有抗增殖和抗转移作用。肠和骨骼中的活化维生素 D 受体维持着钙的吸收和平衡。