6-Thioguanine

• Catalog No.: 88800
• CAS Number: 154-42-7
• M. F.: C5H5N5S
• M. W.: 167.1917
• Purity: ≥96% (HPLC)

SYNONYMS

• Title: 6-硫鸟嘌呤
• IUPAC name: 2-amino-6,7-dihydro-1H-purine-6-thione
• IUPAC Traditional name: 2-aminopurine-6(1h)-thione
• Synonyms: 2-氨基-6-巯嘌呤; 2-Amino-6-purinethiol; 2-Amino-6-mercaptopurine; 2-氨基-6巯基嘌呤

DATABASE IDS

• CAS Number: 154-42-7
• Beilstein Number: 157765
• MDL Number: MFCD00233553
• EC Number: 205-827-2

PROPERTIES

• Empirical Formula (Hill Notation): C5H5N5S
• Grade: purum
• Impurities: ≤3% guanine
• Purity: ≥96% (HPLC)
• Melting Point: ≥300 °C(lit.)
• GHS Signal Word: Danger
• GHS Hazard statements: H301
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• GHS Precautionary statements: P301 + P310
• RID/ADR: UN 2811 6.1/PG 3
• Risk Statements: 25
• RTECS: UP0740000
• Safety Statements: 28-36/37/39-45
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Other Notes
Antineoplastic agent2; substrate for HGPRTase, converted to 6-thio-GMP, which then inhibits vital metabolic sequences in myelocytic and acute lymphocytic leukemia.1
Biochem/physiol Actions
Ribosylated and phosphorylated by the same pathway as natural purine bases; as the nucleotide, inhibits a variety of cellular processes involved in nucleic acid synthesis. Has a long history as an effective treatment of leukemia.1

Description (简体中文)

Other Notes
Antineoplastic agent2; substrate for HGPRTase, converted to 6-thio-GMP, which then inhibits vital metabolic sequences in myelocytic and acute lymphocytic leukemia.1
Biochem/physiol Actions
Ribosylated and phosphorylated by the same pathway as natural purine bases; as the nucleotide, inhibits a variety of cellular processes involved in nucleic acid synthesis. Has a long history as an effective treatment of leukemia.1