Suramin sodium salt

• Catalog No.: 86203
• CAS Number: 129-46-4
• M. F.: C51H34N6Na6O23S6
• M. W.: 1429.17068
• Purity: ≥99.0% (TLC)

SYNONYMS

• IUPAC name: hexasodium 8-{4-methyl-3-[3-({[3-({2-methyl-5-[(4,6,8-trisulfonatonaphthalen-1-yl)carbamoyl]phenyl}carbamoyl)phenyl]carbamoyl}amino)benzamido]benzamido}naphthalene-1,3,5-trisulfonate
• IUPAC Traditional name: hexasodium 8-{4-methyl-3-[3-({[3-({2-methyl-5-[(4,6,8-trisulfonatonaphthalen-1-yl)carbamoyl]phenyl}carbamoyl)phenyl]carbamoyl}amino)benzamido]benzamido}naphthalene-1,3,5-trisulfonate
• Synonyms: Suramine sodium salt

DATABASE IDS

• CAS Number: 129-46-4
• EC Number: 204-949-3
• MDL Number: MFCD00210217
• Beilstein Number: 3694087

PROPERTIES

• Empirical Formula (Hill Notation): C51H34N6Na6O23S6
• Purity: ≥99.0% (TLC)
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS: QM7000000
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Suramin is a polysulfonated naphthylurea anticancer agent that inhibits tumor cell proliferation. It inhibits the activity of topoisomerase II by blocking the binding of the enzyme to DNA. It′s antiangiogenic activity may be related to its ability to bind to and inhibit the activity of several growth factors, including FGFa, FGFb, and PGDF. It uncouples G-proteins from receptors. It is an broad spectrum antagonist at P2X and P2Y purinergic receptors. Suramin has well documented antiprotozoal and anthelmintic activity.

Description (简体中文)

Biochem/physiol Actions
Suramin is a polysulfonated naphthylurea anticancer agent that inhibits tumor cell proliferation. It inhibits the activity of topoisomerase II by blocking the binding of the enzyme to DNA. It′s antiangiogenic activity may be related to its ability to bind to and inhibit the activity of several growth factors, including FGFa, FGFb, and PGDF. It uncouples G-proteins from receptors. It is an broad spectrum antagonist at P2X and P2Y purinergic receptors. Suramin has well documented antiprotozoal and anthelmintic activity.