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Veratridine

Catalog No. 94838 Name Sigma Aldrich
CAS Number 71-62-5 Website http://www.sigmaaldrich.com
M. F. C36H51NO11 Telephone 1-800-521-8956
M. W. 673.79024 Fax
Purity ≥90% (TLC) Email
Storage Chembase ID: 132997

SYNONYMS

IUPAC name
(1R,10R,11S,12S,14R,19S,23S,25R)-1,10,11,12,14,23-hexahydroxy-6,10,19-trimethyl-24-oxa-4-azaheptacyclo[12.12.0.02,11.04,9.015,25.018,23.019,25]hexacosan-22-yl 3,4-dimethoxybenzoate
IUPAC Traditional name
(1R,10R,11S,12S,14R,19S,23S,25R)-1,10,11,12,14,23-hexahydroxy-6,10,19-trimethyl-24-oxa-4-azaheptacyclo[12.12.0.02,11.04,9.015,25.018,23.019,25]hexacosan-22-yl 3,4-dimethoxybenzoate
Synonyms
3-Veratroylveracevine

DATABASE IDS

CAS Number 71-62-5
MDL Number MFCD00082515
Beilstein Number 78875
EC Number 200-758-4

PROPERTIES

Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
GHS Precautionary statements P260-P264-P273-P280-P284-P301 + P310
RID/ADR UN 1544 6.1/PG 1
Risk Statements 26/27/28-36/37/38-48/20-52/53-62
RTECS YX5600000
Safety Statements 26-28-36/37-45-61
Storage Temperature -20°C
Hazard Class 6.1
UN Number 1544
Packing Group 1
German water hazard class 3
GHS Pictograms GHS06
GHS Pictograms GHS08
GHS Signal Word Danger
GHS Hazard statements H300-H310-H315-H319-H330-H335-H361-H373-H412
European Hazard Symbols Highly toxic Highly toxic (T+)
MSDS Link Download
Empirical Formula (Hill Notation) C36H51NO11
Impurities ≤5% solvents
Purity ≥90% (TLC)
Solubility ethanol: soluble50 mg/mL, clear, yellow

DETAILS

Description (English)
Biochem/physiol Actions
Opens voltage-dependent Na+ channels and prevents their inactivation. This, in turn, opens voltage-activated calcium channels, thus increasing intracellular calcium content and inducing neurotransmitter release. Alkaloid neurotoxin which depolarizes excitable tissue; used to increase membrane sodium permeability. Veratridine is cytotoxic to chromaffin cells in vitro.
Description (简体中文)
Biochem/physiol Actions
Opens voltage-dependent Na+ channels and prevents their inactivation. This, in turn, opens voltage-activated calcium channels, thus increasing intracellular calcium content and inducing neurotransmitter release. Alkaloid neurotoxin which depolarizes excitable tissue; used to increase membrane sodium permeability. Veratridine is cytotoxic to chromaffin cells in vitro.

REFERENCES