Veratridine

• Catalog No.: 94838
• CAS Number: 71-62-5
• M. F.: C36H51NO11
• M. W.: 673.79024
• Purity: ≥90% (TLC)

SYNONYMS

• IUPAC name: (1R,10R,11S,12S,14R,19S,23S,25R)-1,10,11,12,14,23-hexahydroxy-6,10,19-trimethyl-24-oxa-4-azaheptacyclo[12.12.0.0^2,^1^1.0^4,^9.0^1^5,^2^5.0^1^8,^2^3.0^1^9,^2^5]hexacosan-22-yl 3,4-dimethoxybenzoate
• IUPAC Traditional name: (1R,10R,11S,12S,14R,19S,23S,25R)-1,10,11,12,14,23-hexahydroxy-6,10,19-trimethyl-24-oxa-4-azaheptacyclo[12.12.0.0^2,^1^1.0^4,^9.0^1^5,^2^5.0^1^8,^2^3.0^1^9,^2^5]hexacosan-22-yl 3,4-dimethoxybenzoate
• Synonyms: 3-Veratroylveracevine

DATABASE IDS

• CAS Number: 71-62-5
• MDL Number: MFCD00082515
• Beilstein Number: 78875
• EC Number: 200-758-4

PROPERTIES

• Personal Protective Equipment: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P260-P264-P273-P280-P284-P301 + P310
• RID/ADR: UN 1544 6.1/PG 1
• Risk Statements: 26/27/28-36/37/38-48/20-52/53-62
• RTECS: YX5600000
• Safety Statements: 26-28-36/37-45-61
• Storage Temperature: -20°C
• Hazard Class: 6.1
• UN Number: 1544
• Packing Group: 1
• German water hazard class: 3
• GHS Signal Word: Danger
• GHS Hazard statements: H300-H310-H315-H319-H330-H335-H361-H373-H412
• European Hazard Symbols: Highly toxic (T+)
• Empirical Formula (Hill Notation): C36H51NO11
• Impurities: ≤5% solvents
• Purity: ≥90% (TLC)
• Solubility: ethanol: soluble50 mg/mL, clear, yellow

DETAILS

Description (English)

Biochem/physiol Actions
Opens voltage-dependent Na+ channels and prevents their inactivation. This, in turn, opens voltage-activated calcium channels, thus increasing intracellular calcium content and inducing neurotransmitter release. Alkaloid neurotoxin which depolarizes excitable tissue; used to increase membrane sodium permeability. Veratridine is cytotoxic to chromaffin cells in vitro.

Description (简体中文)

Biochem/physiol Actions
Opens voltage-dependent Na+ channels and prevents their inactivation. This, in turn, opens voltage-activated calcium channels, thus increasing intracellular calcium content and inducing neurotransmitter release. Alkaloid neurotoxin which depolarizes excitable tissue; used to increase membrane sodium permeability. Veratridine is cytotoxic to chromaffin cells in vitro.