Diethyl chloromethylphosphonate

• Catalog No.: 25030
• CAS Number: 3167-63-3
• M. F.: C5H12ClO3P
• M. W.: 186.573741
• Purity: ≥97.0% (GC)

SYNONYMS

• Title: 氯甲基膦酸二乙酯
• IUPAC name: diethyl (chloromethyl)phosphonate
• IUPAC Traditional name: diethyl chloromethylphosphonate
• Synonyms: NSC 67753; Chloromethylphosphonic acid diethyl ester

DATABASE IDS

• Beilstein Number: 1363361
• MDL Number: MFCD00010189
• EC Number: 221-632-5
• CAS Number: 3167-63-3

PROPERTIES

• Grade: purum
• Linear Formula: ClCH2PO(OC2H5)2
• Purity: ≥97.0% (GC)
• Boiling Point: 109-110 °C/10 mmHg(lit.)
• Density: 1.2 g/mL at 25 °C(lit.)
• Flash Point: 86 °C
• Flash Point: 187 °F
• Refractive Index: n20/D 1.437(lit.)
• Refractive Index: n20/D 1.437
• European Hazard Symbols: Irritant (Xi)
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (简体中文)

Caution
储存时可变为褐色
Application
Reactant involved in:
• Subsequent alkylation after nucleophilic substitution1
• One-pot alkylation-boration of α-haloalkylphosphonates2
• Synthesis of cyclpentane and pyrrolidine derivatives via regioselective insertion reactions3
• Phosphorylation leading to P-containing cyclopropanes4
• Wadsworth-Emmons reactions5
• Ring expansion of zircnacycles via carbenoid insertion6

Description (English)

Caution
may discolor to brown on storage
Application
Reactant involved in:
• Subsequent alkylation after nucleophilic substitution1
• One-pot alkylation-boration of α-haloalkylphosphonates2
• Synthesis of cyclpentane and pyrrolidine derivatives via regioselective insertion reactions3
• Phosphorylation leading to P-containing cyclopropanes4
• Wadsworth-Emmons reactions5
• Ring expansion of zircnacycles via carbenoid insertion6