(±)-Verapamil hydrochloride

• Catalog No.: 94837
• CAS Number: 152-11-4
• M. F.: C27H39ClN2O4
• M. W.: 491.06256
• Purity: ≥99.0% (TLC)

SYNONYMS

• IUPAC name: 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile hydrochloride
• IUPAC Traditional name: veraβ hydrochloride
• Synonyms: 5-[N-(3,4-Dimethoxyphenylethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile hydrochloride

DATABASE IDS

• EC Number: 205-800-5
• CAS Number: 152-11-4
• PubChem SID: 24890064
• Beilstein Number: 3647093
• MDL Number: MFCD00055208

PROPERTIES

• Linear Formula: (CH3O)2C6H3CH2CH2N(CH3)(CH2)3C[C6H3(OCH3)2][CH(CH3)2]CN · HCl
• Purity: ≥99.0% (TLC)
• Melting Point: 142 °C (dec.)(lit.)
• Solubility: methanol: soluble50 mg/mL, clear, colorless
• GHS Signal Word: Danger
• GHS Hazard statements: H301-H311-H331
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• GHS Precautionary statements: P261-P280-P301 + P310-P311
• RID/ADR: UN 2811 6.1/PG 3
• Risk Statements: 23/24/25
• RTECS: YV8320000
• Safety Statements: 36/37-45
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
α1-adrenoceptor antagonist; L-type calcium channel blocker. Blocks L-type Ca2+ channels in smooth and cardiac muscle, induces apoptosis of human primary and metastatic colon adenocarcinoma cells in vitro. Drug resistance reversal agent acting on Pgp, e.g. decrease renal tubule elimination of digoxin. Increases basal ATPase activity of Pgp. Substrate of Cyp3A4 and CYP2C6.

Description (简体中文)

Biochem/physiol Actions
α1-adrenoceptor antagonist; L-type calcium channel blocker. Blocks L-type Ca2+ channels in smooth and cardiac muscle, induces apoptosis of human primary and metastatic colon adenocarcinoma cells in vitro. Drug resistance reversal agent acting on Pgp, e.g. decrease renal tubule elimination of digoxin. Increases basal ATPase activity of Pgp. Substrate of Cyp3A4 and CYP2C6.