L-Thyroxine

• Catalog No.: 89405
• CAS Number: 51-48-9
• M. F.: C15H11I4NO4
• M. W.: 776.87002
• Purity: ≥97.0% (sum of enantiomers, HPLC)

SYNONYMS

• Title: L-甲状腺素
• IUPAC name: (2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid
• IUPAC Traditional name: levothyroxine
• Synonyms: 3,3′,5,5″-四碘代-L-甲状腺原氨酸; 3,3′,5,5″-Tetraiodo-L-thyronine; T4; 3-[4-(4-羟基-3,5-二碘苯氧基)-3,5-二碘苯基]-L-丙氨酸; 3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanine

DATABASE IDS

• EC Number: 200-101-1
• MDL Number: MFCD00002595
• CAS Number: 51-48-9
• Beilstein Number: 2228515

PROPERTIES

• Linear Formula: HOC6H2(I)2OC6H2(I)2CH2CH(NH2)CO2H
• Purity: ≥97.0% (sum of enantiomers, HPLC)
• Gene Information: human ... TTR(7276)
• Melting Point: 223 °C (dec.)(lit.)
• Melting Point: ~235 °C (dec.)
• Optical Rotation: [α]20/D -5.3±0.5°, c = 1% in ethanol/1 M NaOH (2:1)
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS: YP2833500
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
L-Thyroxine (T4) and triiodo-L-thyronine (T3) are iodine-containing hormones produced from thyroglobulin in the thyroid follicular cells. The stimulation of metabolic rate and regulation of growth and development by these hormones appear to be due to their effects on DNA transcription and, thus, protein synthesis.
Other Notes
Review1

Description (简体中文)

Biochem/physiol Actions
L甲状腺素 (T4) 和三碘代-L-甲状腺原氨酸 (T3) 为含碘激素，由甲状腺卵泡细胞中的甲状腺球蛋白制备。这些激素对代谢率的刺激以及对生长发展的调节似乎归因于它们对 DNA 转录的作用，进而影响蛋白质的合成。
Other Notes
Review1