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Isoniazid

Catalog No. 58980 Name Sigma Aldrich
CAS Number 54-85-3 Website http://www.sigmaaldrich.com
M. F. C6H7N3O Telephone 1-800-521-8956
M. W. 137.13928 Fax
Purity ≥99.0% (NT) Email
Storage Chembase ID: 827

SYNONYMS

Title
异烟肼
IUPAC name
pyridine-4-carbohydrazide
IUPAC Traditional name
isoniazid
Synonyms
异烟酸肼
Isonicotinic acid hydrazide
Isonicotinic hydrazide
雷米封
INH

DATABASE IDS

CAS Number 54-85-3
Beilstein Number 119374
MDL Number MFCD00006426
EC Number 200-214-6

PROPERTIES

Empirical Formula (Hill Notation) C6H7N3O
Grade for fluorescence
Grade purum
Purity ≥99.0% (NT)
Fluorescence λex 433 nm; λem 500 nm in methanol (after derivatization with progesterone and as complex with Al3+)
Melting Point 170-173 °C
Melting Point 171-173 °C(lit.)
GHS Pictograms GHS07
GHS Signal Word Warning
GHS Hazard statements H302-H315
European Hazard Symbols Harmful Harmful (Xn)
MSDS Link Download
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Risk Statements 22-38
RTECS NS1751850
Safety Statements 37
German water hazard class 3

DETAILS

Description (English)
Application
Used for fluorescence detection in the high-performance liquid chromatography of olefinic 3-ketosteroids1
Biochem/physiol Actions
Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations.
Description (简体中文)
Application
用于 HPLC 荧光检测烯-3-甾酮1
Biochem/physiol Actions
针对结核菌的抗生素,抑制分枝菌酸的生物合成。由肝脏 N-乙酰转移酶 (NAT) 和 细胞色素 P450 2E1 (CYP2E1) 代谢形成肝毒素。选择性诱导 CYP2E1 的表达。可逆抑制 CYP2C19 和 CYP3A4 的活性,在临床相关浓度下机械性地灭活 CYP1A2、CYP2A6、CYP2C19 和 CYP3A4。

REFERENCES