Isoniazid

• Catalog No.: 58980
• CAS Number: 54-85-3
• M. F.: C6H7N3O
• M. W.: 137.13928
• Purity: ≥99.0% (NT)

SYNONYMS

• Title: 异烟肼
• IUPAC name: pyridine-4-carbohydrazide
• IUPAC Traditional name: isoniazid
• Synonyms: 异烟酸肼; Isonicotinic acid hydrazide; Isonicotinic hydrazide; 雷米封; INH

DATABASE IDS

• CAS Number: 54-85-3
• Beilstein Number: 119374
• MDL Number: MFCD00006426
• EC Number: 200-214-6

PROPERTIES

• Empirical Formula (Hill Notation): C6H7N3O
• Grade: for fluorescence
• Grade: purum
• Purity: ≥99.0% (NT)
• Fluorescence: λex 433 nm; λem 500 nm in methanol (after derivatization with progesterone and as complex with Al3+)
• Melting Point: 170-173 °C
• Melting Point: 171-173 °C(lit.)
• GHS Signal Word: Warning
• GHS Hazard statements: H302-H315
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• Risk Statements: 22-38
• RTECS: NS1751850
• Safety Statements: 37
• German water hazard class: 3

DETAILS

Description (English)

Application
Used for fluorescence detection in the high-performance liquid chromatography of olefinic 3-ketosteroids1
Biochem/physiol Actions
Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations.

Description (简体中文)

Application
用于 HPLC 荧光检测烯-3-甾酮1
Biochem/physiol Actions
针对结核菌的抗生素，抑制分枝菌酸的生物合成。由肝脏 N-乙酰转移酶 (NAT) 和 细胞色素 P450 2E1 (CYP2E1) 代谢形成肝毒素。选择性诱导 CYP2E1 的表达。可逆抑制 CYP2C19 和 CYP3A4 的活性，在临床相关浓度下机械性地灭活 CYP1A2、CYP2A6、CYP2C19 和 CYP3A4。