1-Formylpiperidine

• Catalog No.: 47725
• CAS Number: 2591-86-8
• M. F.: C6H11NO
• M. W.: 113.15764
• Purity: ≥99.0% (GC)

SYNONYMS

• Title: 1-甲酰哌啶
• IUPAC name: piperidine-1-carbaldehyde
• IUPAC Traditional name: N-formylpiperidine
• Synonyms: NFP; Piperidine-1-carboxaldehyde; 哌啶-1-甲醛; N-Carbaldehyde piperidine

DATABASE IDS

• Beilstein Number: 107697
• MDL Number: MFCD00006483
• CAS Number: 2591-86-8
• EC Number: 219-986-0

PROPERTIES

• Empirical Formula (Hill Notation): C6H11NO
• Grade: purum
• Purity: ≥99.0% (GC)
• Boiling Point: 222 °C(lit.)
• Density: 1.019 g/mL at 25 °C(lit.)
• Flash Point: 102 °C
• Flash Point: 215.6 °F
• Refractive Index: n20/D 1.484(lit.)
• Refractive Index: n20/D 1.485
• Vapor Pressure: 0.1 mmHg ( 25 °C)
• GHS Signal Word: Danger
• GHS Hazard statements: H302-H311-H315-H319-H335
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
• GHS Precautionary statements: P261-P280-P305 + P351 + P338-P312
• RID/ADR: UN 2810 6.1/PG 3
• Risk Statements: 21/22-36/37/38
• RTECS: TN0380000
• Safety Statements: 26-36/37
• Hazard Class: 6.1
• UN Number: 2810
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Other Notes
Used in formyl transfer to Grignard reagents7
Application
Reactant for:
• Direct amidation of azoles with formamides via metal-free C-H activation in the presence of tert-butyl perbenzoate1
• Vilsmeier-type reactions of pyrazoles with amides in the presence of phosphorous oxychloride2
• CO-free aminocarbonylation of N-substituted formamides with aryl iodides/bromides catalyzed by palladium acetate and Xantphos for synthesis of arylamides3
• Synthesis of alternating copolymers for organic photovoltaic applications4
• One-pot double functionalization of π-deficient heterocyclic lithium reagents5
• Synthesis of thermally stable piezofluorochromic aggregation-induced emission compounds6

Description (简体中文)

Other Notes
用于甲酰基转移至格氏试剂的反应7
Application
Reactant for:
• Direct amidation of azoles with formamides via metal-free C-H activation in the presence of tert-butyl perbenzoate1
• Vilsmeier-type reactions of pyrazoles with amides in the presence of phosphorous oxychloride2
• CO-free aminocarbonylation of N-substituted formamides with aryl iodides/bromides catalyzed by palladium acetate and Xantphos for synthesis of arylamides3
• Synthesis of alternating copolymers for organic photovoltaic applications4
• One-pot double functionalization of π-deficient heterocyclic lithium reagents5
• Synthesis of thermally stable piezofluorochromic aggregation-induced emission compounds6