Apamin

• Catalog No.: 10796
• CAS Number: 24345-16-2
• M. F.: C79H131N31O24S4
• M. W.: 2027.33874
• Purity: ≥80% peptide basis

SYNONYMS

• IUPAC name: 3-[(1R,4S,7S,13S,16S,19S,22S,25S,28R,31S,34S,37S,40R,47S,50R)-50-amino-4-(4-aminobutyl)-34,37-bis(3-carbamimidamidopropyl)-40-{[(1S)-3-carbamoyl-1-{[(1S)-3-carbamoyl-1-{[(1S)-1-carbamoyl-2-(1H-imidazol-5-yl)ethyl]carbamoyl}propyl]carbamoyl}propyl]carbamoyl}-47-(carbamoylmethyl)-19-[(1R)-1-hydroxyethyl]-7,22,31-trimethyl-25-(2-methylpropyl)-2,5,8,14,17,20,23,26,29,32,35,38,46,49-tetradecaoxo-42,43,52,53-tetrathia-3,6,9,15,18,21,24,27,30,33,36,39,45,48-tetradecaazatricyclo[26.16.10.0^9,^1^3]tetrapentacontan-16-yl]propanoic acid
• IUPAC Traditional name: 3-[(1R,4S,7S,13S,16S,19S,22S,25S,28R,31S,34S,37S,40R,47S,50R)-50-amino-4-(4-aminobutyl)-34,37-bis(3-carbamimidamidopropyl)-40-{[(1S)-3-carbamoyl-1-{[(1S)-3-carbamoyl-1-{[(1S)-1-carbamoyl-2-(3H-imidazol-4-yl)ethyl]carbamoyl}propyl]carbamoyl}propyl]carbamoyl}-47-(carbamoylmethyl)-19-[(1R)-1-hydroxyethyl]-7,22,31-trimethyl-25-(2-methylpropyl)-2,5,8,14,17,20,23,26,29,32,35,38,46,49-tetradecaoxo-42,43,52,53-tetrathia-3,6,9,15,18,21,24,27,30,33,36,39,45,48-tetradecaazatricyclo[26.16.10.0^9,^1^3]tetrapentacontan-16-yl]propanoic acid

DATABASE IDS

• CAS Number: 24345-16-2
• EC Number: 246-182-7
• MDL Number: MFCD00167944

PROPERTIES

• Biological Source: from bee venom
• Empirical Formula (Hill Notation): C79H131N31O24S4
• Purity: ≥80% peptide basis
• Purity: ≥95% (HPLC)
• Solubility: 0.05 M acetic acid: soluble5 mg/mL, clear, colorless to faintly yellow
• RTECS: CD6899900
• Safety Statements: 22-24/25
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Amino Acid Sequence
Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys-Ala-Arg-Arg-Cys-Gln-Gln-His-NH2 [Disulfide Bridges: 1-11, 3-15]
Biochem/physiol Actions
The only polypeptide neurotoxin that is known to pass the blood-brain barrier. Blocks ATP-type Ca+2-activated K+ channels.
Other Notes
A neurotoxin which blocks a class of Ca2+-activated K+ channels1; Biochemistry and pharmacology of2

Description (简体中文)

Amino Acid Sequence
Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys-Ala-Arg-Arg-Cys-Gln-Gln-His-NH2 [Disulfide Bridges: 1-11, 3-15]
Biochem/physiol Actions
The only polypeptide neurotoxin that is known to pass the blood-brain barrier. Blocks ATP-type Ca+2-activated K+ channels.
Other Notes
A neurotoxin which blocks a class of Ca2+-activated K+ channels1; Biochemistry and pharmacology of2