Dimethyl 3,3′-dithiopropionimidate dihydrochloride

• Catalog No.: 43780
• CAS Number: 38285-78-8
• M. F.: C8H18Cl2N2O2S2
• M. W.: 309.27672
• Purity: ≥95.0% (AT)

SYNONYMS

• Title: 3,3′-二硫代双丙亚氨酸二甲酯 二盐酸盐
• IUPAC name: methyl 3-[(3-imino-3-methoxypropyl)disulfanyl]propanecarboximidate dihydrochloride
• IUPAC Traditional name: methyl 3-[(3-imino-3-methoxypropyl)disulfanyl]propanecarboximidate dihydrochloride
• Synonyms: Wang/Richards’ reagent; DTBP; Dimethyl 3,3′-dithio-bis(propionimidate) dihydrochloride; 3,3′-二硫代丙亚氨酸二甲酯 二盐酸盐; Wang/Richards 试剂

DATABASE IDS

• PubChem SID: 24867398
• CAS Number: 38285-78-8
• MDL Number: MFCD00043245

PROPERTIES

• Empirical Formula (Hill Notation): C8H16N2O2S2 · 2HCl
• Grade: purum
• Purity: ≥95.0% (AT)
• GHS Signal Word: Warning
• GHS Hazard statements: H315
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• Risk Statements: 38
• Safety Statements: 36
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Analysis Note
product decomposes at 111-115°C, residual melts at 160-164°C
Caution
The reagant is readily hydrolyzed at neutral pH. Avoid use of reducing agents during coupling reactions.
Other Notes
Cleavable bifunctional reagent used for cross-linking of membrane proteins and hemoglobin4; For the preparation of an activated solid support5; Cross-linking of a cytochrome oxidase complex6
Note that the amidine linkage preserves original primary amine positive charge. The disulfide linkage is cleavable by mild reduction. Incorporates an eight atom linker.
Application
Reactant for:
• Synthesis of glutathione-sensitive cross-linked polyethylenimine gene vector1
• Preparation of cyclodextrin-containing polymers designed for gene delivery2
• Crosslinking of chick oviduct progesterone-receptor subunits3

Description (简体中文)

Analysis Note
产品在 111-115°C 时分解，残留物在 160-164°C 时熔化
Caution
该试剂在中性 pH 下易水解。在偶联反应时应避免使用还原剂。
Other Notes
可裂解双官能试剂，用于膜蛋白和血红蛋白的交联4；制备活化的固体载体5；细胞色素氧化酶复合物的交联6
注意：脒键具有初始伯胺的正电荷。可由轻度还原反应裂解二硫键。含有一个八原子连接基。
Application
Reactant for:
• Synthesis of glutathione-sensitive cross-linked polyethylenimine gene vector1
• Preparation of cyclodextrin-containing polymers designed for gene delivery2
• Crosslinking of chick oviduct progesterone-receptor subunits3