Eucalyptol

• Catalog No.: DB03852
• CAS Number: 470-82-6
• M. F.: C10H18O
• M. W.: 154.24932

SYNONYMS

• IUPAC name: 1,3,3-trimethyl-2-oxabicyclo[2.2.2]octane
• IUPAC Traditional name: eucalyptol
• Synonyms: Cucalyptol; FEMA No. 2465; UNII-RV6J6604TK; Eukalyptol [czech]; 1,8-epoxy-p-menthane; 4,7,7-trimethyl-8-oxabicyclo[2.2.2]octane; limonene oxide; eucalyptole; 2-Oxabicyclo(2.2.2)octane, 1,3,3-trimethyl-; Cineolum; Eucalyptol (usan); Eucapur; Eukalyptol; P-cineole; WLN: T66 A B AOTJ B1 B1 F1; {2-Oxa-1,3,3-trimethylbicyclo[2.2.2]octane}; {2-Oxabicyclo[2.2.2]octane,} 1,3,3-trimethyl-; 1,8-Cineole; 1,8-cineol; cajeputol; 1,8-oxido-p-menthane; cineole; cineol; 1,3,3-Trimethyl-2-oxabicyclo(2.2.2)octane; 1,3,3-Trimethyl-2-oxabicyclo[2,2,2]octan; 1,3,3-Trimethyl-2-oxabicyclo[2.2.2]octane; 1,3,3-trimethyl-2-oxabicyclo[2.2.2]octane (ACD/Name 4.0); 2-Oxa-1,3,3-trimethylbicyclo(2.2.2)octane; 2-Oxabicyclo[2.2.2]octane, 1,3,3-trimethyl-; BIDD:ER0481; Casella-med brand of cineole; Eucalyptol [usan]; Eucalyptus oil; Soledum; Terpan; Zedoary oil; Zineol; p-Menthane, 1,8-epoxy-; p-Menthane, 1,8-epoxy- (VAN); {1,3,3-Trimethyl-2-oxabicyclo[2.2.2]octane}; 1,8-cineol (eucalyptol); 2-Oxa-1,3,3-trimethylbicyclo[2.2.2]octane; CNL; Eucalyptol (natural)

DATABASE IDS

• CAS Number: 470-82-6

PROPERTIES

• Hydrophobicity(logP): 2.74 [GRIFFIN,S ET AL. (1999)]
• Solubility: 3.5 mg/mL at 21 oC [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

DETAILS

Description (English)

• Drug Groups: nutraceutical
• Description: Eucalyptol is a natural organic compound which is a colorless liquid. It is a cyclic ether and a monoterpenoid. Eucalyptol is an ingredient in many brands of mouthwash and cough suppressant. It controls airway mucus hypersecretion and asthma via anti-inflammatory cytokine inhibition. Eucalyptol is an effective treatment for nonpurulent rhinosinusitis. Eucalyptol reduces inflammation and pain when applied topically. It kills leukaemia cells in vitro.
• Toxicity: Oral, rat LD50: 2480 mg/kg
• Affected Organisms: Humans and other mammals
• References: Bastos VP, Gomes AS, Lima FJ, Brito TS, Soares PM, Pinho JP, Silva CS, Santos AA, Souza MH, Magalhaes PJ: Inhaled 1,8-Cineole Reduces Inflammatory Parameters in Airways of Ovalbumin-Challenged Guinea Pigs. Basic Clin Pharmacol Toxicol. 2010 Aug 16. [Pubmed]
• External Links: Wikipedia

REFERENCES

• Bastos VP, Gomes AS, Lima FJ, Brito TS, Soares PM, Pinho JP, Silva CS, Santos AA, Souza MH, Magalhaes PJ: Inhaled 1,8-Cineole Reduces Inflammatory Parameters in Airways of Ovalbumin-Challenged Guinea Pigs. Basic Clin Pharmacol Toxicol. 2010 Aug 16. Pubmed