L-Buthionine-sulfoximine

• Catalog No.: 19175
• CAS Number: 83730-53-4
• M. F.: C8H18N2O3S
• M. W.: 222.30512
• Purity: ≥96.0% (TLC)

SYNONYMS

• IUPAC name: (2S)-2-amino-4-[butyl(imino)oxo-λ^6-sulfanyl]butanoic acid
• IUPAC Traditional name: (2S)-2-amino-4-[butyl(imino)oxo-λ^6-sulfanyl]butanoic acid
• Synonyms: L-BSO

DATABASE IDS

• Beilstein Number: 2367136
• CAS Number: 83730-53-4
• MDL Number: MFCD00067000

PROPERTIES

• Empirical Formula (Hill Notation): C8H18N2O3S
• Purity: ≥96.0% (TLC)
• Melting Point: 224-228 °C (dec.)
• Optical Rotation: [α]20/D +33±1°, c = 1% in 1 M HCl
• Solubility: H2O: soluble50 mg/mL, clear, colorless to faintly yellow
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS: EK7713440
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Blocks cellular resistance to chemotherapy by inhibiting γ-glutamylcysteine synthetase, a key enzyme in glutathione biosynthesis.2 Used to induce experimental glutathione deficiency, to investigate roles of glutathione in cellular processes.1
Other Notes
Potent specific inhibitor of γ-glutamylcysteine synthetase2
Application
Used to induce experimental glutathione deficiency, to investigate roles of glutathione in cellular processes.1

Description (简体中文)

Biochem/physiol Actions
Blocks cellular resistance to chemotherapy by inhibiting γ-glutamylcysteine synthetase, a key enzyme in glutathione biosynthesis.2 Used to induce experimental glutathione deficiency, to investigate roles of glutathione in cellular processes.1
Other Notes
Potent specific inhibitor of γ-glutamylcysteine synthetase2
Application
Used to induce experimental glutathione deficiency, to investigate roles of glutathione in cellular processes.1