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Benzamidine hydrochloride hydrate_Molecular_structure_CAS_206752-36-5)
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Benzamidine hydrochloride hydrate

Catalog No. 12073 Name Sigma Aldrich
CAS Number 206752-36-5 Website http://www.sigmaaldrich.com
M. F. C7H11ClN2O Telephone 1-800-521-8956
M. W. 174.62804 Fax
Purity ≥98.0% (calc. based on dry substance, AT) Email
Storage Chembase ID: 75239

SYNONYMS

Title
苯甲脒 盐酸盐 水合物
IUPAC name
benzenecarboximidamide hydrate hydrochloride
IUPAC Traditional name
benzamidine hydrate hydrochloride
Synonyms
Benzamidinium chloride
苄脒 盐酸盐
盐酸苄脒
Amidinobenzene hydrochloride
Benzenecarboximidamide hydrochloride

DATABASE IDS

EC Number 216-795-4
Beilstein Number 3594959
CAS Number 206752-36-5
MDL Number MFCD00066285

PROPERTIES

Grade purum
Impurities 15-20% water
Linear Formula C6H5C(=NH)NH2 · HCl · xH2O
Purity ≥98.0% (calc. based on dry substance, AT)
Melting Point 86-88 °C(lit.)
GHS Pictograms GHS07
GHS Signal Word Warning
GHS Hazard statements H315-H319-H335
European Hazard Symbols Irritant Irritant (Xi)
MSDS Link Download
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
GHS Precautionary statements P261-P305 + P351 + P338
Risk Statements 36/37/38
Safety Statements 26-36
German water hazard class 3

DETAILS

Description (English)
Biochem/physiol Actions
Benzamidine HCl is a reversible inhibitor of trypsin, trypsin-like enzymes, and serine proteases. A concentration of approximately 1 mM is used for general protease inhibition. To inhibit proteases from yeast, a range of 0.5 to 4.0 mM is used and it is for the most part interchangeable with pepstatin A.In addition to being a strong competitive inhibitor of trypsin, benzamidine HCl has been also shown to be a strong competitive inhibitor of thrombin and plasmin. It was also found to be as effective as aprotinin in the prevention of glucagon degradation in human plasma.
Peptidase inhibitor.
Other Notes
Proteolytic inhibitor.; Prevents the destruction of thyrotropin-releasing hormone by blood1; Inhibitor in the RIA of glucagon in plasma2
Preparation Note
Benzamidine HCl is soluble in water and alcohol. Solubility testing in water at a concentration of 50 mg/ml yields a clear solution with heating. Benzamidine HCl is sensitive to oxidation. It is recommended to prepare solutions fresh each time in degassed water prior to use. However, frozen aliquots stored under inert gas, to exclude air, may be stable for a short time. Insufficient information is available to assess the shelf-life of a frozen solution.
Description (简体中文)
Biochem/physiol Actions
盐酸苯甲脒为胰蛋白酶、胰蛋白样酶以及丝氨酸蛋白酶的可逆抑制剂。 采用大约 1mM 的浓度可抑制常用蛋白酶。要抑制来自酵母的蛋白酶,所用浓度范围为 0.5 至 4.0mM,并且通常它可与胃蛋白酶抑制剂互换。 除了可用作胰蛋白酶的强效竞争性抑制剂外,盐酸苯甲脒还可作为凝血酶和纤溶酶的强效竞争性抑制剂。而且还发现盐酸苯甲脒在阻止人血浆中的胰高血糖素降解方面与抑肽酶效果相当。
肽酶抑制剂。
Other Notes
蛋白酶解抑制剂。;通过血液阻止促甲状腺素释放激素受到破坏1;对血浆中胰高血糖素进行放射免疫分析的抑制剂2
Preparation Note
盐酸苯甲脒可溶于水和乙醇。 在水中进行浓度测试,50mg/ml 时加热可得到澄清溶液。盐酸苯甲脒易于氧化。建议每次使用前在脱气水中配制新鲜溶液。然而,储存在惰性气体中以排除空气的冷冻等分溶液,短时间内可保持稳定。用于评估冷冻溶液保质期的信息不足。

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