5-Azacytidine

• Catalog No.: 11385
• CAS Number: 320-67-2
• M. F.: C8H12N4O5
• M. W.: 244.20468
• Purity: ≥97.0% (HPLC)

SYNONYMS

• Title: 5-氮杂胞嘧啶核苷
• IUPAC name: 4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydro-1,3,5-triazin-2-one
• IUPAC Traditional name: azacitidine
• Synonyms: 4-Amino-1-(β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one; 阿扎胞苷; 4-氨基-1-(β-D-呋喃核糖基)-1,3,5-三嗪-2(1H)-酮; Ladakamycin

DATABASE IDS

• Beilstein Number: 620461
• MDL Number: MFCD00006539
• CAS Number: 320-67-2
• EC Number: 206-280-2

PROPERTIES

• Empirical Formula (Hill Notation): C8H12N4O5
• Purity: ≥97.0% (HPLC)
• Melting Point: 226-232 °C (dec.)(lit.)
• GHS Signal Word: Danger
• GHS Hazard statements: H302-H350
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P201-P308 + P313
• Risk Statements: 45-46-22
• RTECS: XZ3017500
• Safety Statements: 22-36/37/39-45
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Application
Cancerostatic agent with weak antibiotic activity (gram-positive)
Biochem/physiol Actions
A potent growth inhibitor and cytotoxic agent; inhibits DNA methyltransferase, an important regulatory mechanism of gene expression, gene activation and silencing.

Description (简体中文)

Application
Cancerostatic agent with weak antibiotic activity (gram-positive)
Biochem/physiol Actions
一种强效生长抑制剂及细胞毒素剂，抑制 DNA 甲基转移酶，一种基因表达、基因激活和沉默的重要调节机制。