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Dipyrone

Catalog No. D8890 Name Sigma Aldrich
CAS Number 68-89-3 Website http://www.sigmaaldrich.com
M. F. C13H16N3NaO4S Telephone 1-800-521-8956
M. W. 333.33861 Fax
Purity Email
Storage Chembase ID: 4361

SYNONYMS

Title
安乃近
IUPAC name
sodium [(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(methyl)amino]methanesulfonate
IUPAC Traditional name
sodium metamizole(1-)

DATABASE IDS

MDL Number MFCD00020783
EC Number 200-694-7
PubChem SID 24894234
CAS Number 68-89-3

PROPERTIES

Grade analytical standard
Linear Formula C13H16N3O4SNa
GHS Pictograms GHS08
GHS Signal Word Danger
GHS Hazard statements H317-H334
European Hazard Symbols Harmful Harmful (Xn)
MSDS Link Download
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
GHS Precautionary statements P261-P280-P342 + P311
Risk Statements 42/43
RTECS PB1300000
Safety Statements 36
Storage Temperature 2-8°C
German water hazard class 2

DETAILS

Description (简体中文)
Biochem/physiol Actions
非甾体抗炎药,与吗啡并服时,能增强镇痛作用,延缓耐受。安乃近是环氧酶-3 (COX-3) 具有相对选择性的抑制剂,对 COX-1 的活性较低,对 COX-2 没有活性。以几种模式阻止 PGE2 引起的痛觉过敏。
Description (English)
Biochem/physiol Actions
A non-steroidal anti-inflammatory drug that, when coadministered with morphine, potentiates its antinociceptive action and delays the development of tolerance. Dipyrone is a relatively selective inhibitor of cyclooxygenase-3 (COX-3), with lower activity against COX-1 and no activity against COX-2. Blocks PGE2-induced hyperalgesia in several models.

REFERENCES