Dipyrone

• Catalog No.: D8890
• CAS Number: 68-89-3
• M. F.: C13H16N3NaO4S
• M. W.: 333.33861

SYNONYMS

• Title: 安乃近
• IUPAC name: sodium [(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(methyl)amino]methanesulfonate
• IUPAC Traditional name: sodium metamizole(1-)

DATABASE IDS

• MDL Number: MFCD00020783
• EC Number: 200-694-7
• PubChem SID: 24894234
• CAS Number: 68-89-3

PROPERTIES

• Grade: analytical standard
• Linear Formula: C13H16N3O4SNa
• GHS Signal Word: Danger
• GHS Hazard statements: H317-H334
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS Precautionary statements: P261-P280-P342 + P311
• Risk Statements: 42/43
• RTECS: PB1300000
• Safety Statements: 36
• Storage Temperature: 2-8°C
• German water hazard class: 2

DETAILS

Description (简体中文)

Biochem/physiol Actions
非甾体抗炎药，与吗啡并服时，能增强镇痛作用，延缓耐受。安乃近是环氧酶-3 (COX-3) 具有相对选择性的抑制剂，对 COX-1 的活性较低，对 COX-2 没有活性。以几种模式阻止 PGE2 引起的痛觉过敏。

Description (English)

Biochem/physiol Actions
A non-steroidal anti-inflammatory drug that, when coadministered with morphine, potentiates its antinociceptive action and delays the development of tolerance. Dipyrone is a relatively selective inhibitor of cyclooxygenase-3 (COX-3), with lower activity against COX-1 and no activity against COX-2. Blocks PGE2-induced hyperalgesia in several models.