Metformin hydrochloride

• Catalog No.: 04635
• CAS Number: 1115-70-4
• M. F.: C4H12ClN5
• M. W.: 165.62458

SYNONYMS

• Title: 二甲双胍 盐酸盐
• IUPAC name: 1-carbamimidamido-N,N-dimethylmethanimidamide hydrochloride
• IUPAC Traditional name: metformin hydrochloride
• Synonyms: 1,1-Dimethylbiguanide hydrochloride; 甲福明 盐酸盐; 二甲双胍; Metformin

DATABASE IDS

• MDL Number: MFCD00012582
• EC Number: 214-230-6
• CAS Number: 1115-70-4

PROPERTIES

• Linear Formula: NH2C(=NH)NHC(=NH)N(CH3)2 · HCl
• Pharmacopeia Traceability: traceable to PhEur M0605000
• Pharmacopeia Traceability: traceable to USP 1396309
• Melting Point: 223-226 °C(lit.)
• GHS Signal Word: Warning
• GHS Hazard statements: H302-H315-H319
• European Hazard Symbols: Harmful (Xn)
• GHS Precautionary statements: P305 + P351 + P338
• Risk Statements: 22-36/38
• RTECS: DU1800000
• Safety Statements: 26-36
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Metformin is an antidiabetic agent that reduces blood glucose levels and improves insulin sensitivity. Its metabolic effects, including the inhibition of hepatic gluconeogenesis, are mediated at least in part by activation of the LKB1-AMPK (AMP-activated protein kinase) pathway. Activation of this pathway also appears to be involved in the antiproliferative and proapoptotic actions of metformin in cancer cell lines.

Description (简体中文)

Biochem/physiol Actions
甲福明是一种抗糖尿病药，可降低血糖水平，提高胰岛素灵敏度。其代谢作用（包括抑制肝脏糖异生作用）至少部分是通过激活 LKB1-AMPK（AMP-活化蛋白激酶）通路进行介导。该通路的激活也涉及到癌细胞系中甲福明的抗增殖和促凋亡作用。