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Safrole

Catalog No. 84130 Name Sigma Aldrich
CAS Number 94-59-7 Website http://www.sigmaaldrich.com
M. F. C10H10O2 Telephone 1-800-521-8956
M. W. 162.1852 Fax
Purity ≥96.0% (GC) Email
Storage Chembase ID: 107360

SYNONYMS

Title
黄樟素
IUPAC name
5-(prop-2-en-1-yl)-2H-1,3-benzodioxole
IUPAC Traditional name
sassafras
Synonyms
4-烯丙基-1,2-亚甲基二氧基苯
5-Allyl-1,3-benzodioxole
5-烯丙基-1,3-苯并二噁茂
4-Allyl-1,2-methylenedioxybenzene

DATABASE IDS

CAS Number 94-59-7
Beilstein Number 136380
EC Number 202-345-4
MDL Number MFCD00005841

PROPERTIES

Empirical Formula (Hill Notation) C10H10O2
Grade purum
Purity ≥96.0% (GC)
Boiling Point 232-234 °C(lit.)
Density 1.099 g/mL at 20 °C
Density 1.095 g/mL at 25 °C(lit.)
Flash Point 100 °C
Flash Point 212 °F
Melting Point 11.2 °C(lit.)
Refractive Index n20/D 1.537(lit.)
Refractive Index n20/D 1.538
Vapor Pressure 1 mmHg ( 63.8 °C)
GHS Pictograms GHS07
GHS Pictograms GHS08
GHS Signal Word Danger
GHS Hazard statements H302-H341-H350
European Hazard Symbols Toxic Toxic (T)
MSDS Link Download
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
GHS Precautionary statements P201-P281-P308 + P313
Risk Statements 45-22-68
RTECS CY2800000
Safety Statements 53-45
German water hazard class 3

DETAILS

Description (English)
Biochem/physiol Actions
Safrole is a naturally-occurring genotoxic compound found in Sassafras root and Areca (betel) quid. It is a hepatocarcinogen, and safrole-DNA adducts have also been seen in oral cancers of Areca users. Metabolites of safrole form adducts with DNA and induce chromasomal aberrations and sister chromatid exchanges.
Other Notes
Principal constituent of sassafras oil
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Description (简体中文)
Biochem/physiol Actions
黄樟素是在黄樟根和槟榔嚼块中发现的天然基因毒性化合物。它是致肝癌物,并且黄樟素-DNA 加合物还见于槟榔消费者的口腔癌。黄樟素的代谢产物与 DNA 形成加合物,并且会诱导染色体畸变和姐妹染色单体交换。
Other Notes
黄樟油的主要成分
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REFERENCES