Hydroxyurea

• Catalog No.: 55291
• CAS Number: 127-07-1
• M. F.: CH4N2O2
• M. W.: 76.05466
• Purity: ≥98.0% (N)

SYNONYMS

• Title: 羟基脲
• IUPAC name: hydroxyurea
• IUPAC Traditional name: hydroxyurea
• Synonyms: Hydroxycarbamide

DATABASE IDS

• EC Number: 204-821-7
• CAS Number: 127-07-1
• Beilstein Number: 1741548
• PubChem SID: 24879294
• MDL Number: MFCD00007943

PROPERTIES

• Linear Formula: NH2CONHOH
• Purity: ≥98.0% (N)
• Gene Information: human ... CA1(759), CA2(760), CYP1A2(1544), RRM1(6240)
• Melting Point: 135-140 °C
• GHS Signal Word: Danger
• GHS Hazard statements: H340-H361
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P201-P281-P308 + P313
• Risk Statements: 46-63
• RTECS: YT4900000
• Safety Statements: 53-36/37-45
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase.

Description (简体中文)

Biochem/physiol Actions
抗肿瘤剂。通过形成自由基硝基氧灭活核糖核苷还原酶，自由基硝基氧可结合到酶活性位点的酪氨酰自由基。这可阻断脱氧核苷酸的合成，从而抑制 DNA 合成，并且诱导细胞周期同步化或 S-期细胞死亡。