2-Deoxy-D-glucose

• Catalog No.: 31060
• CAS Number: 154-17-6
• M. F.: C6H12O5
• M. W.: 164.15648
• Purity: ≥98.0% (HPLC)

SYNONYMS

• Title: D-2-脱氧葡萄糖
• IUPAC name: (3R,4S,5R)-3,4,5,6-tetrahydroxyhexanal
• IUPAC Traditional name: deoxyglucose
• Synonyms: 2-脱氧-D-葡糖; 2-Deoxy-D-arabinohexose

DATABASE IDS

• CAS Number: 154-17-6
• MDL Number: MFCD00151328
• EC Number: 205-823-0
• Beilstein Number: 1723331

PROPERTIES

• Empirical Formula (Hill Notation): C6H12O5
• Purity: ≥98.0% (HPLC)
• Melting Point: 146-147 °C(lit.)
• Melting Point: 148-153 °C
• Optical Rotation: [α]20/D +46.5±2°, 45 hr, c = 0.5% in H2O
• Solubility: H2O: soluble50 mg/mL, clear, colorless to faintly yellow
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP. In vitro, 2-Deoxyglucose has been shown to induce autophagy, increase ROS production, and activate AMPK.1

Description (简体中文)

Biochem/physiol Actions
2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP. In vitro, 2-Deoxyglucose has been shown to induce autophagy, increase ROS production, and activate AMPK.1