Staurosporine from Streptomyces sp.

• Catalog No.: 85660
• CAS Number: 62996-74-1
• M. F.: C28H26N4O3
• M. W.: 466.53104
• Purity: ≥95.0% (HPLC)

SYNONYMS

• IUPAC name: (2S,3R,4R,6S)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^2,^6.0^7,^2^8.0^8,^1^3.0^1^5,^1^9.0^2^0,^2^7.0^2^1,^2^6]nonacosa-8(13),9,11,14(28),15(19),20(27),21,23,25-nonaen-16-one
• IUPAC Traditional name: (2S,3R,4R,6S)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^2,^6.0^7,^2^8.0^8,^1^3.0^1^5,^1^9.0^2^0,^2^7.0^2^1,^2^6]nonacosa-8(13),9,11,14(28),15(19),20(27),21,23,25-nonaen-16-one
• Synonyms: Antibiotic AM-2282

DATABASE IDS

• CAS Number: 62996-74-1
• Beilstein Number: 1060573
• MDL Number: MFCD00077402

PROPERTIES

• Empirical Formula (Hill Notation): C28H26N4O3
• Purity: ≥95.0% (HPLC)
• GHS Signal Word: Danger
• GHS Hazard statements: H340-H350
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P201-P308 + P313
• Risk Statements: 45-46
• Safety Statements: 53-45
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Potent inhibitor of phospholipid/calcium-dependent protein kinase. Inhibits the upregulation of VEGF expression in tumor cells.
Other Notes
A potent inhibitor of phospholipid / calcium dependent protein kinase1,2; Inhibits the respiratory burst and induces exocytosis in human neutrophils3

Description (简体中文)

Biochem/physiol Actions
Potent inhibitor of phospholipid/calcium-dependent protein kinase. Inhibits the upregulation of VEGF expression in tumor cells.
Other Notes
A potent inhibitor of phospholipid / calcium dependent protein kinase1,2; Inhibits the respiratory burst and induces exocytosis in human neutrophils3