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1-(tert-Butyldimethylsilyl)imidazole_Molecular_structure_CAS_54925-64-3)
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1-(tert-Butyldimethylsilyl)imidazole

Catalog No. 19920 Name Sigma Aldrich
CAS Number 54925-64-3 Website http://www.sigmaaldrich.com
M. F. C9H18N2Si Telephone 1-800-521-8956
M. W. 182.33812 Fax
Purity ≥95.0% (GC) Email
Storage Chembase ID: 139854

SYNONYMS

Title
1-(叔丁基二甲基甲硅烷基)咪唑
IUPAC name
1-(tert-butyldimethylsilyl)-1H-imidazole
IUPAC Traditional name
1-(tert-butyldimethylsilyl)imidazole
Synonyms
TBDMSIM

DATABASE IDS

EC Number 259-398-1
MDL Number MFCD00011682
CAS Number 54925-64-3
Beilstein Number 606695

PROPERTIES

Empirical Formula (Hill Notation) C9H18N2Si
Grade purum
Purity ≥95.0% (GC)
Boiling Point 53 °C/0.2 mmHg(lit.)
Density 0.939 g/mL at 25 °C(lit.)
Flash Point 99 °C
Flash Point 210.2 °F
Refractive Index n20/D 1.481(lit.)
Refractive Index n20/D 1.481
GHS Pictograms GHS07
GHS Signal Word Warning
GHS Hazard statements H315-H319-H335
European Hazard Symbols Irritant Irritant (Xi)
MSDS Link Download
Personal Protective Equipment Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
GHS Precautionary statements P261-P305 + P351 + P338
Risk Statements 36/37/38
Safety Statements 26-36
German water hazard class 3

DETAILS

Description (English)
Other Notes
Convenient reagent for introducing the sterically crowded tert-butyldimethylsilyl group in unhindered hydroxy groups.; It is mostly used for derivatizations of steroid hormones and nucleosides to allow GC and MS measurements 1,2,3; Reagent of choice for the preparation of very moisture sensitive tert-butyldimethylsilyl derivatives of hydroxy-compounds as no aqueous work-up is necessary4
Description (简体中文)
Other Notes
在无位阻的羟基中引入大空间位阻的叔丁基二甲基甲硅烷基的简便试剂;常用于类固醇激素和核苷的衍生化作用,以便进行气相色谱和质谱测定1,2,3;制备羟基化合物的叔丁基二甲基甲硅烷基衍生物的精选试剂,这种衍生物对水非常敏感,反应不涉及含水步骤4

REFERENCES