1-(tert-Butyldimethylsilyl)imidazole

• Catalog No.: 19920
• CAS Number: 54925-64-3
• M. F.: C9H18N2Si
• M. W.: 182.33812
• Purity: ≥95.0% (GC)

SYNONYMS

• Title: 1-(叔丁基二甲基甲硅烷基)咪唑
• IUPAC name: 1-(tert-butyldimethylsilyl)-1H-imidazole
• IUPAC Traditional name: 1-(tert-butyldimethylsilyl)imidazole
• Synonyms: TBDMSIM

DATABASE IDS

• EC Number: 259-398-1
• MDL Number: MFCD00011682
• CAS Number: 54925-64-3
• Beilstein Number: 606695

PROPERTIES

• Empirical Formula (Hill Notation): C9H18N2Si
• Grade: purum
• Purity: ≥95.0% (GC)
• Boiling Point: 53 °C/0.2 mmHg(lit.)
• Density: 0.939 g/mL at 25 °C(lit.)
• Flash Point: 99 °C
• Flash Point: 210.2 °F
• Refractive Index: n20/D 1.481(lit.)
• Refractive Index: n20/D 1.481
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• German water hazard class: 3

DETAILS

Description (English)

Other Notes
Convenient reagent for introducing the sterically crowded tert-butyldimethylsilyl group in unhindered hydroxy groups.; It is mostly used for derivatizations of steroid hormones and nucleosides to allow GC and MS measurements 1,2,3; Reagent of choice for the preparation of very moisture sensitive tert-butyldimethylsilyl derivatives of hydroxy-compounds as no aqueous work-up is necessary4

Description (简体中文)

Other Notes
在无位阻的羟基中引入大空间位阻的叔丁基二甲基甲硅烷基的简便试剂；常用于类固醇激素和核苷的衍生化作用，以便进行气相色谱和质谱测定1,2,3；制备羟基化合物的叔丁基二甲基甲硅烷基衍生物的精选试剂，这种衍生物对水非常敏感，反应不涉及含水步骤4