(Trimethylsilyl)diazomethane solution

• Catalog No.: 92738
• CAS Number: 18107-18-1
• M. F.: C4H10N2Si
• M. W.: 114.2211

SYNONYMS

• Title: 三甲基硅烷化重氮甲烷 溶液
• IUPAC name: (diazomethyl)trimethylsilane
• IUPAC Traditional name: trimethylsilyldiazomethane
• Synonyms: (三甲硅烷)重氮甲烷; (Diazomethyl)trimethylsilane

DATABASE IDS

• Beilstein Number: 1902903
• MDL Number: MFCD00053946
• CAS Number: 18107-18-1
• PubChem SID: 24889702

PROPERTIES

• Concentration: ~2 M in hexane
• Grade: technical
• Linear Formula: (CH3)3SiCHN2
• Flash Point: -26 °C
• Flash Point: -14.8 °F
• GHS Signal Word: Danger
• GHS Hazard statements: H225-H304-H315-H330-H336-H350-H361f-H370-H411
• European Hazard Symbols: Flammable (F)
• European Hazard Symbols: Highly toxic (T+)
• European Hazard Symbols: Nature polluting (N)
• Personal Protective Equipment: Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
• GHS Precautionary statements: P201-P210-P260-P273-P281-P284
• RID/ADR: UN 1992 3/PG 2
• Risk Statements: 45-11-26-38-39/26-51/53-62-65-67
• Safety Statements: 53-28-36/37-45-61-62
• Hazard Class: 3
• UN Number: 1992
• Packing Group: 2
• German water hazard class: 3

DETAILS

Description (English)

Application
Reactant for preparation of:
• Macrolactam analogs of the natural product macrolide (-)-A26771B with improved metabolic stability and antibacterial activity1
• Aigialomycin D analogues as protein kinase inhibitors for cancer treatment2
• Unnatural α-amino acid derivatives containing gem-bisphosphonates via Michael addition reaction3
• Capped 4-methylumbelliferyl hyaluronan disaccharides and tetrasaccharides as potential hyaluronidase substrates4
• Stictamides A-C as matrix metallopeptidase 12 (MMP12) inhibitors with antitumor invasion activity5
• Endothelin converting enzyme (ECE) Inhibitors WS 75624A and WS 75624B via a cross-metathesis approach6
• Ent-kaurene derivatives as anti-inflammatory agents7
• Desmosdumotin C analogs as potent antitumor agents acting via activation of spindle assembly checkpoint8
• Imidazolo[2,1-b]benzothiazole derivatives as potential p53 inhibitors9

Description (简体中文)

Application
Reactant for preparation of:
• Macrolactam analogs of the natural product macrolide (-)-A26771B with improved metabolic stability and antibacterial activity1
• Aigialomycin D analogues as protein kinase inhibitors for cancer treatment2
• Unnatural α-amino acid derivatives containing gem-bisphosphonates via Michael addition reaction3
• Capped 4-methylumbelliferyl hyaluronan disaccharides and tetrasaccharides as potential hyaluronidase substrates4
• Stictamides A-C as matrix metallopeptidase 12 (MMP12) inhibitors with antitumor invasion activity5
• Endothelin converting enzyme (ECE) Inhibitors WS 75624A and WS 75624B via a cross-metathesis approach6
• Ent-kaurene derivatives as anti-inflammatory agents7
• Desmosdumotin C analogs as potent antitumor agents acting via activation of spindle assembly checkpoint8
• Imidazolo[2,1-b]benzothiazole derivatives as potential p53 inhibitors9