Melittin from honey bee venom

• Catalog No.: 63650
• CAS Number: 20449-79-0
• M. F.: C131H229N39O31
• M. W.: 2846.46266
• Purity: ~70% (HPLC)

SYNONYMS

• IUPAC name: (2S)-2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-6-amino-2-[(2S,3S)-2-[(2S)-2-[(2S)-2-[(2S,3S)-2-[(2S)-2-[(2S)-2-{[(2S)-1-[(2S)-2-{2-[(2S,3R)-2-[(2S,3R)-2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-2-[(2S)-2-{2-[(2S,3S)-2-(2-aminoacetamido)-3-methylpentanamido]acetamido}propanamido]-3-methylbutanamido]-4-methylpentanamido]hexanamido]-3-methylbutanamido]-4-methylpentanamido]-3-hydroxybutanamido]-3-hydroxybutanamido]acetamido}-4-methylpentanoyl]pyrrolidin-2-yl]formamido}propanamido]-4-methylpentanamido]-3-methylpentanamido]-3-hydroxypropanamido]-3-(1H-indol-3-yl)propanamido]-3-methylpentanamido]hexanamido]-5-carbamimidamidopentanamido]hexanamido]-5-carbamimidamidopentanamido]-4-carbamoylbutanamido]pentanediamide
• IUPAC Traditional name: (2S)-2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-6-amino-2-[(2S,3S)-2-[(2S)-2-[(2S)-2-[(2S,3S)-2-[(2S)-2-[(2S)-2-{[(2S)-1-[(2S)-2-{2-[(2S,3R)-2-[(2S,3R)-2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-2-[(2S)-2-{2-[(2S,3S)-2-(2-aminoacetamido)-3-methylpentanamido]acetamido}propanamido]-3-methylbutanamido]-4-methylpentanamido]hexanamido]-3-methylbutanamido]-4-methylpentanamido]-3-hydroxybutanamido]-3-hydroxybutanamido]acetamido}-4-methylpentanoyl]pyrrolidin-2-yl]formamido}propanamido]-4-methylpentanamido]-3-methylpentanamido]-3-hydroxypropanamido]-3-(1H-indol-3-yl)propanamido]-3-methylpentanamido]hexanamido]-5-carbamimidamidopentanamido]hexanamido]-5-carbamimidamidopentanamido]-4-carbamoylbutanamido]pentanediamide

DATABASE IDS

• MDL Number: MFCD00076868
• CAS Number: 20449-79-0

PROPERTIES

• Empirical Formula (Hill Notation): C131H229N39O31
• Purity: ~70% (HPLC)
• GHS Signal Word: Danger
• GHS Hazard statements: H301-H311-H331
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• GHS Precautionary statements: P261-P280-P301 + P310-P311
• Risk Statements: 23/24/25
• Safety Statements: 36/37/39-45
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Amino Acid Sequence
Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2
Biochem/physiol Actions
Binds calmodulin in a Ca2+-dependent manner; inhibits Na+-K+-ATPase.
Other Notes
The principle hemolytic component of honeybee venom.
Main component of the honeybee venom. It is a basic hydrophobic peptide which alters membrane permeability1; Interference with enzymes2; Interaction with calmodulin3; Used in the affinity chromatographic purification of calmodulin4

Description (简体中文)

Amino Acid Sequence
Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2
Biochem/physiol Actions
Binds calmodulin in a Ca2+-dependent manner; inhibits Na+-K+-ATPase.
Other Notes
The principle hemolytic component of honeybee venom.
Main component of the honeybee venom. It is a basic hydrophobic peptide which alters membrane permeability1; Interference with enzymes2; Interaction with calmodulin3; Used in the affinity chromatographic purification of calmodulin4