Indomethacin

• Catalog No.: 57413
• CAS Number: 53-86-1
• M. F.: C19H16ClNO4
• M. W.: 357.78764
• Purity: ≥99.0% (TLC)

SYNONYMS

• Title: 吲哚美辛
• IUPAC name: 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid
• IUPAC Traditional name: indomethacin
• Synonyms: 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetic acid; 1-(4-氯苯甲酰基)-5-甲氧基-2-甲基-3-吲哚乙酸

DATABASE IDS

• MDL Number: MFCD00057095
• EC Number: 200-186-5
• CAS Number: 53-86-1
• Beilstein Number: 497341

PROPERTIES

• Empirical Formula (Hill Notation): C19H16ClNO4
• Purity: ≥99.0% (TLC)
• Melting Point: 155-162 °C
• Solubility: ethanol: soluble50 mg/mL, clear, yellow-green
• GHS Signal Word: Danger
• GHS Hazard statements: H300
• European Hazard Symbols: Highly toxic (T+)
• GHS Precautionary statements: P264-P301 + P310
• RID/ADR: UN 2811 6.1/PG 1
• Risk Statements: 28
• RTECS: NL3500000
• Safety Statements: 28-36/37-45
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: 1
• German water hazard class: 3
• Personal Protective Equipment: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

DETAILS

Description (English)

Biochem/physiol Actions
Cyclooxygenase (COX) inhibitor that is relatively selective for COX-1.
Other Notes
Blocks prostaglandin biosynthesis.; Topography of prostaglandin H synthase1; Cyclooxygenase inhibitor2

Description (简体中文)

Biochem/physiol Actions
环加氧酶 (COX) 抑制剂，对 COX-1 的选择性相对较高。
Other Notes
Blocks prostaglandin biosynthesis.; Topography of prostaglandin H synthase1; Cyclooxygenase inhibitor2