Puromycin dihydrochloride from Streptomyces alboniger

• Catalog No.: 82595
• CAS Number: 58-58-2
• M. F.: C22H31Cl2N7O5
• M. W.: 544.43144
• Purity: ≥98.0% (HPLC)

SYNONYMS

• Title: Puromycin dihydrochloride 二盐酸盐 来源于白色链球菌
• IUPAC name: (2S)-2-amino-N-[(2S,3S,4R,5R)-5-[6-(dimethylamino)-9H-purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-methoxyphenyl)propanamide dihydrochloride
• IUPAC Traditional name: puromycin dihydrochloride
• Synonyms: 3′-[α-Amino-p-methoxyhydrocinnamamido]-3′-deoxy-N,N-dimethyladenosine 二盐酸盐; 3′-[α-Amino-p-methoxyhydrocinnamamido]-3′-deoxy-N,N-dimethyladenosine dihydrochloride

DATABASE IDS

• EC Number: 200-387-8
• MDL Number: MFCD00012691
• Beilstein Number: 3853613
• CAS Number: 58-58-2

PROPERTIES

• Empirical Formula (Hill Notation): C22H29N7O5 · 2HCl
• Purity: ≥98.0% (HPLC)
• GHS Signal Word: Warning
• GHS Hazard statements: H302
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• Risk Statements: 22
• RTECS: AU7355000
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Other Notes
Causes premature chain termination in protein synthesis by acting as an analog of aminoacyl-tRNA.; Inhibitor of aminopeptidase and enkephalinase. Photoincorporation of puromycin into rat liver ribosomes1; Immunosuppressive effect2
Biochem/physiol Actions
Nucleoside antibiotic. Protein synthesis inhibitor that causes premature chain termination by acting as an analog of the 3′-terminal end of aminoacyl-tRNA. Prevents growth of bacteria, protozoa, algae, and mammalian cells. Acts very quickly and can kill 99% of cells within 2 days, the resistance gene (puromycin acetyltransferase) gives very effective protection.

Description (简体中文)

Other Notes
Causes premature chain termination in protein synthesis by acting as an analog of aminoacyl-tRNA.; Inhibitor of aminopeptidase and enkephalinase. Photoincorporation of puromycin into rat liver ribosomes1; Immunosuppressive effect2
Biochem/physiol Actions
Nucleoside antibiotic. Protein synthesis inhibitor that causes premature chain termination by acting as an analog of the 3′-terminal end of aminoacyl-tRNA. Prevents growth of bacteria, protozoa, algae, and mammalian cells. Acts very quickly and can kill 99% of cells within 2 days, the resistance gene (puromycin acetyltransferase) gives very effective protection.