3,4-Dichloroisocoumarin

• Catalog No.: 35913
• CAS Number: 51050-59-0
• M. F.: C9H4Cl2O2
• M. W.: 215.03286
• Purity: ≥99.0% (TLC)

SYNONYMS

• IUPAC name: 3,4-dichloro-1H-isochromen-1-one
• IUPAC Traditional name: 3,4-dichloroisocoumarin
• Synonyms: 3,4-DCI; 3,4-Dichloro-2-benzopyran-1-one

DATABASE IDS

• MDL Number: MFCD00036960
• Beilstein Number: 6802625
• CAS Number: 51050-59-0

PROPERTIES

• Empirical Formula (Hill Notation): C9H4Cl2O2
• Purity: ≥99.0% (TLC)
• GHS Signal Word: Danger
• GHS Hazard statements: H301-H315-H319-H335
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• GHS Precautionary statements: P261-P301 + P310-P305 + P351 + P338
• RID/ADR: UN 2811 6.1/PG 3
• Risk Statements: 25-36/37/38
• Safety Statements: 26-36
• Storage Temperature: 2-8°C
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Other Notes
Effective concentration 5-100 μM.
Inhibitor of serine proteases1; Inhibition of porcine pancreatic elastase2
Quantity
Half-life = 20 min at pH 7.5.
Substrates
Serine protease inhibitor. Active towards a wide range of serine proteases including granzymes. Not active toward β-lactamases.
Biochem/physiol Actions
Inhibitor of serine proteases1 and porcine pancreatic elastase2. Treatment of proteasomes leads to rapid inactivation of chymotrypsin-like activity and slower inactivation of other proteases.3

Description (简体中文)

Other Notes
Effective concentration 5-100 μM.
Inhibitor of serine proteases1; Inhibition of porcine pancreatic elastase2
Quantity
Half-life = 20 min at pH 7.5.
Substrates
Serine protease inhibitor. Active towards a wide range of serine proteases including granzymes. Not active toward β-lactamases.
Biochem/physiol Actions
Inhibitor of serine proteases1 and porcine pancreatic elastase2. Treatment of proteasomes leads to rapid inactivation of chymotrypsin-like activity and slower inactivation of other proteases.3