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cis-Diammineplatinum(II) dichloride

Catalog No. 33422 Name Sigma Aldrich
CAS Number 15663-27-1 Website http://www.sigmaaldrich.com
M. F. Cl2H6N2Pt Telephone 1-800-521-8956
M. W. 300.04504 Fax
Purity ≥96.0% (Pt) Email
Storage Chembase ID: 111049

SYNONYMS

Title
顺铂
IUPAC name
dichloroplatinum diamine
IUPAC Traditional name
platinum(II) chloride diamine
Synonyms
cis-Dichlorodiammine platinum(II)
顺-二氯二氨基铂(II)
cis-Platinum(II) diammine dichloride
Cisplatin
顺式-二胺二氯铂
顺氯氨铂

DATABASE IDS

CAS Number 15663-27-1
MDL Number MFCD00011623
EC Number 239-733-8

PROPERTIES

Linear Formula Pt(NH3)2Cl2
Purity ≥96.0% (Pt)
Melting Point 270 °C(lit.)
GHS Pictograms GHS05
GHS Pictograms GHS06
GHS Pictograms GHS08
GHS Signal Word Danger
GHS Hazard statements H300-H318-H350
European Hazard Symbols Toxic Toxic (T)
MSDS Link Download
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
GHS Precautionary statements P201-P264-P280-P301 + P310-P305 + P351 + P338-P308 + P313
RID/ADR UN 3288 6.1/PG 2
Risk Statements 45-25-41
RTECS TP2450000
Safety Statements 53-26-39-45
Hazard Class 6.1
UN Number 3288
Packing Group 2
German water hazard class 3

DETAILS

Description (简体中文)
Biochem/physiol Actions
强效的铂基抗肿瘤剂。与 DNA 二核苷酸 d(pGpG) 形成细胞毒性加合物,诱导链内交联。
Other Notes
Antitumor compound1; Review (chemistry and properties)2,3
Description (English)
Biochem/physiol Actions
Potent platinum-based antineoplastic agent. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand cross-links.
Other Notes
Antitumor compound1; Review (chemistry and properties)2,3

REFERENCES