cis-Diammineplatinum(II) dichloride

• Catalog No.: 33422
• CAS Number: 15663-27-1
• M. F.: Cl2H6N2Pt
• M. W.: 300.04504
• Purity: ≥96.0% (Pt)

SYNONYMS

• Title: 顺铂
• IUPAC name: dichloroplatinum diamine
• IUPAC Traditional name: platinum(II) chloride diamine
• Synonyms: cis-Dichlorodiammine platinum(II); 顺-二氯二氨基铂(II); cis-Platinum(II) diammine dichloride; Cisplatin; 顺式-二胺二氯铂; 顺氯氨铂

DATABASE IDS

• CAS Number: 15663-27-1
• MDL Number: MFCD00011623
• EC Number: 239-733-8

PROPERTIES

• Linear Formula: Pt(NH3)2Cl2
• Purity: ≥96.0% (Pt)
• Melting Point: 270 °C(lit.)
• GHS Signal Word: Danger
• GHS Hazard statements: H300-H318-H350
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P201-P264-P280-P301 + P310-P305 + P351 + P338-P308 + P313
• RID/ADR: UN 3288 6.1/PG 2
• Risk Statements: 45-25-41
• RTECS: TP2450000
• Safety Statements: 53-26-39-45
• Hazard Class: 6.1
• UN Number: 3288
• Packing Group: 2
• German water hazard class: 3

DETAILS

Description (简体中文)

Biochem/physiol Actions
强效的铂基抗肿瘤剂。与 DNA 二核苷酸 d(pGpG) 形成细胞毒性加合物，诱导链内交联。
Other Notes
Antitumor compound1; Review (chemistry and properties)2,3

Description (English)

Biochem/physiol Actions
Potent platinum-based antineoplastic agent. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand cross-links.
Other Notes
Antitumor compound1; Review (chemistry and properties)2,3