α-(4-Pyridyl N-oxide)-N-tert-butylnitrone

• Catalog No.: 20583
• CAS Number: 66893-81-0
• M. F.: C10H14N2O2
• M. W.: 194.23036
• Purity: ≥98.0% (HPLC)

SYNONYMS

• Title: α-(4-吡啶基-1-氧)-N-叔丁基硝基酮
• IUPAC name: 4-[(tert-butyl-oxo-$l^{5}-azanylidene)methyl]pyridin-1-ium-1-olate
• IUPAC Traditional name: 4-[(tert-butyl-oxo-$l^{5}-azanylidene)methyl]pyridin-1-ium-1-olate
• Synonyms: N-(4-吡啶基亚甲基)-叔丁胺-N,N′-二氧化物; POBN; N-tert-Butyl-α-(4-pyridyl)nitrone N′-oxide; N-(4-Pyridylmethylene)-tert-butylamine N,N′-dioxide; N-叔丁基-α-(4-吡啶基-1-氧)硝酮

DATABASE IDS

• MDL Number: MFCD00041022
• Beilstein Number: 1453764
• EC Number: 266-512-3
• PubChem SID: 24852352
• CAS Number: 66893-81-0

PROPERTIES

• Empirical Formula (Hill Notation): C10H14N2O2
• Grade: purum
• Purity: ≥98.0% (HPLC)
• Melting Point: 183-185 °C(lit.)
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Application
Spin trap reagent used to measure ethanol oxidation to 1-hydroxyethyl radical (HER) which can bind to protein. Has also been used in studies of DNA methylation, iron-mediated polyunsaturated fatty acid peroxidation, and free-radical formation by Alzheimer β-amyloid peptide. The formation of hydroxyl radical in chondrocytes and cartilage has been detected using POBN.
Other Notes
Spin trap for radicals useful for the detection and identification of short-lived radicals; it is more water-soluble than PBN1,2

Description (简体中文)

Application
用于测定乙醇氧化生成 1-羟乙基自由基 (HER) 的自旋捕捉剂，HER 可与蛋白质结合。还用于研究 DNA 甲基化反应、铁介导的多不饱和脂肪酸过氧化反应以及通过阿尔茨海默 β-淀粉样肽形成自由基。已使用 POBN 检测到软骨细胞和软骨中羟自由基的形成。
Other Notes
用于检测和识别短寿命自由基的自由基自旋捕捉剂；它比 PBN 更易溶于水1,2